高原脱适应期间尿酸水平的变化与血细胞压积的关系探究  

Study on the relationship between uric acid level change and hematocrit during high altitude deacclimation

作　　者：吴云波 李中华 Wu Yunbo;Li Zhonghua

机构地区：[1]中国人民武装警察部队烟台特勤疗养中心,264000

出　　处：《中国疗养医学》2020年第9期911-913,共3页Chinese Journal of Convalescent Medicine

摘　　要：目的探究高原脱适应期间尿酸(UA)水平的变化与血细胞压积(HCT)的关系。方法选取高原官兵246例为高原组(海拔>4000 m有34例,3000~4000 m有97例,<3000 m有115例),选取同期平原地区来院疗养的150例官兵为平原组。通过调查回访高原平时健康状况和组织健康查体获得各项分析数据。采用match-t检验、单因素方差分析和Pearson直线相关分析法来分析HCT和血清UA的变化和相关性。P<0.05表示差异有统计学意义。结果高原组HCT和血清UA浓度分别为(55.8±6.4)%和(411.7±36.3)μmol/L,均高于平原组(P<0.05)。在高原组中,HCT随海拔的升高而增加,在返回平原后逐渐降低,且在入院后的前3 d下降最显著,组间差异有高度统计学意义(P<0.01)。在高原海拔>3000 m组中,血清UA水平在返回平原第3天时较高原平时有明显增高,而后又逐渐下降,甚至在第18天时能恢复到正常水平(海拔3000~4000 m组),且随海拔的增高,变化幅度更显著(3000~4000 m组,P<0.0422;>4000 m组,P<0.0001)。但在<3000 m组中,血清UA变化差异无统计学意义(P>0.05)。直线相关分析显示,海拔>3000 m时,HCT的降低与血清UA的升高存在相关性(r=0.826、0.647);返回平原第3天时HCT与血清UA的相关性最高,且在海拔>4000 m时比海拔<4000 m时相关性更显著(P<0.05)。但海拔<3000 m时不存在相关性。结论从海拔>3000 m的高原返回平原的脱适应期,血清UA浓度先增高后降低,并与HCT的变化存在相关性,且海拔越高相关性越显著。当从海拔在3000~4000 m的高原返回平原的第18天时,血清UA即能恢复到正常水平,而海拔超过4000 m时,或需更长时间恢复。Objective To explore the relationship between uric acid(UA)level change and hematocrit(HCT)during high altitude deacclimation.Methods 246 cases of plateau officers and soldiers were selected as the plateau group(34 cases with altitude of>4000 m,97 cases with altitude of 3000~4000 m,115 cases with altitude of 3000 m).150 cases of officers and soldiers coming to the hospital for recuperation in the same period from the plain area were selected as the control group.Through the investigation of the health status of the plateau and the organized health examinations to obtain various analytical data.The changes and correlations between HCT and serum UA were analyzed by using the match-T test,one-way anOVA and Pearson linear correlation analysis.P<0.05 indicated that the difference was statistically significant.Results The concentrations of HCT and UA in the plateau group were(55.8±6.4)%and(411.7±36.3)mol/L,respectively,higher than those in the plain group(P<0.05).In the plateau group,HCT increased with the elevation of altitude,gradually decreased after returning to the plain,and decreased most significantly in the first 3 days after admission,with a highly statistically significant difference between groups(P<0.01).In the group with altitude of>3000 m,the serum UA level increased significantly on the 3rd day after returning to the plain,then gradually decreased,and even returned to the normal level on the 18th day(in the 3000~4000 m group),and the change range was more significant with the increase of altitude(in the group of 3000~4000 m,P<0.0422;in the group of>4000 m,P<0.0001).However,there was no significant difference in serum uric acid in the group of<3000 m(P>0.05).Linear correlation analysis showed that there was a correlation between the decrease of HCT and the increase of serum UA at the altitude of>3000 m(r=0.826,0.647).The correlation between HCT and UA was the highest on the 3rd day of returning to the plain,and the correlation was more significant at>4000 m than at<4000 m(P<0.05).But there was no correl

关 键 词：高原脱适应症 尿酸 血细胞压积 

分 类 号：R82[医药卫生—临床医学]