瓜环与药物地丹诺辛的络合作用研究  

Study of the host-guest interaction between cucurbit[n]urils and didanosine

作　　者：李春荣[1] 孟铁宏[1] 罗阳[2] 张威[2] 姜艳萍[1] 刘仕云[1] 范颖[2] 肖昕[2] LI Chun-rong;MENG Tie-hong;LUO Yang;ZHANG Wei;JIANG Yan-ping;LIU Shi-yun;FAN Ying;XIAO Xin(Public Course Teaching Department,Qiannan Medical College for Nationalities,Duyun 558000,China;Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province,Guizhou University,Guiyang 550025,China)

机构地区：[1]黔南民族医学高等专科学校公共课教学部,贵州都匀558000 [2]贵州大学贵州省大环化学及超分子化学重点实验室,贵州贵阳550025

出　　处：《化学研究与应用》2020年第8期1421-1426,共6页Chemical Research and Application

基　　金：贵州省自然科学基金项目(黔科合基础[2019]1301,[2020]1Y051)资助;黔南民族医学高等专科学校基金项目(QNYZ201902,QNYZ201706)资助;黔南州社会发展项目(黔南州科合社字[2016]1号,黔南州科合社字[2017]19号)资助。

摘　　要：选取了三种具有不同空腔大小的瓜环:对称四甲基六元瓜环(TMeQ[6])、七元瓜环(Q[7])、八元瓜环(Q[8]),并应用核磁共振技术、热重分析技术、红外光谱等分析手段探究了这三种瓜环与药物分子地丹诺辛(DDI)的相互作用。实验结果表明:这三种具有不同空腔大小的瓜环与DDI之间具有不同的作用模式。DDI与Q[7]、Q[8]发生了主客体作用,地丹诺辛的呋喃环基团进入了瓜环的空腔。而且形成包结配合物后,DDI的热稳定性得到显著提高。而DDI与TMeQ[6]并没有发生作用。Three kinds of cucurbit[n]urils including TMeQ[6],Q[7]and Q[8]were employed as hosts,the supramolecular self-assembly between these cucurbit[n]urils with didanosin(DDI)guest had been studied by 1HNMR spectroscopy,TGA Thermogravimetric analysis and FTIR spectroscopy.The results showed that there were different modes of interaction between these different cucurbit[n]uril and DDI.for the Q[7]-DDI system,the furan ring and partial alkyl chain of the guest molecule reside within the cavity of the Q[7]and Q[8]host,and the thermal stability of DDI was also significantly improved after forming the inclusion complex.While there was not interaction between TMeQ[6]and DDI.

关 键 词：瓜环 药物分子 地丹诺辛 主客体作用 

分 类 号：O641.3[理学—物理化学]