研究冠状动脉支架置入术治疗老年单支血管病变冠心病的临床疗效  

Clinical effect of intracoronary stent implantation in the treatment of in elderly patients with single vessel coronary artery disease

作　　者：卢佳 黄畇入 LU Jia;HUANG Yun-ru(First People’s Hospital of Nankang District,Ganzhou 341400,China)

机构地区：[1]江西赣州南康区第一人民医院,341400

出　　处：《中国实用医药》2020年第20期32-34,共3页China Practical Medicine

摘　　要：目的分析老年单支血管病变冠心病(CAD)应用冠状动脉支架置入术治疗的临床效果。方法60例老年单支血管病变冠心病患者,根据抽签法分为实验组和参照组,各30例。参照组选择保守治疗,实验组选择冠状动脉支架置入术治疗。对比两组治疗前后心肌纤维化指标[血清Ⅰ型前胶原(PCⅠ)、Ⅲ型前胶原(PCⅢ)、层粘蛋白(LN)、透明质酸(HA)及醛固酮(ALD)]及心功能指标[左心室舒张末期内径(LVEDD)、N末端B型脑钠肽前体(NT-proBNP)、左心室射血分数(LVEF)和6 min步行试验(6MWD)]改善情况。结果治疗后,两组PCⅠ、PCⅢ、LN、HA、ALD均较治疗前降低,且实验组低于参照组,差异有统计学意义(P<0.05)。治疗后,实验组LVEDD(39.83±4.94)mm、NT-proBNP(1.76±0.73)ng/L小于参照组的(46.85±5.52)mm、(2.87±1.53)ng/L,LVEF(62.32±6.29)%、6MWD(401.24±32.27)m大于参照组的(54.29±6.37)%、(340.57±37.19)m,差异均有统计学意义(P<0.05)。结论在老年单支血管病变冠心病的临床治疗中,采用冠状动脉支架置入术可较好的缓解心肌纤维化,改善心功能,促进患者身体的快速康复,值得临床推广。Objective To analyze the clinical effect of intracoronary stent implantation in the treatment of in elderly patients with single vessel coronary artery disease(CAD).Methods A total of 60 elderly patients with single vessel coronary artery disease were divided into experimental group and control group by lottery method,with 30 cases in each group.Patients in the reference group were treated conservatively,and patients in the experimental group were treated with intracoronary stent implantation.The improvement of myocardial fibrosis indicators[serum procollagenⅠ(PCⅠ),procollagenⅢ(PCⅢ),laminin(LN),hyaluronic acid(HA)and aldosterone(ALD)]and cardiac function indicators[left ventricular end-diastolic diameter(LVEDD),N-terminal pro-brain natriuretic peptide(NT-proBNP),left ventricular ejection fraction(LVEF)and 6-min walking distance(6 MWD)]were compared between the two groups.Results After treatment,PC I,PCⅢ,LN,HA and ALD of the two groups was lower than those before treatment,and the experimental group was lower than those of the control group,and the difference was statistically significant(P<0.05).After treatment,LVEDD(39.83±4.94)mm and NT-proBNP(1.76±0.73)ng/L of the experimental group was less than those of the control group(46.85±5.52)mm,(2.87±1.53)ng/L,and LVEF(62.32±6.29)%and 6 MWD(401.24±32.27)m was greater than that of the control group(54.29±6.37)%and(340.57±37.19)m,and the difference was statistically significant(P<0.05).Conclusion In the clinical treatment of elderly patients with single vessel coronary artery disease,intracoronary stent implantation can better alleviate myocardial fibrosis,improve cardiac function,and promote rapid recovery of patients,which is worthy of clinical promotion.

关 键 词：冠状动脉支架置入术 老年单支血管病变冠心病 心肌纤维化 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]