富血小板血浆治疗糖尿病足难愈性创面的作用研究  

Effects of the platelet-rich plasma on diabetic foot refractory wounds

作　　者：杨荣华[1] 阮树斌[1] 林泽鹏[1] 信琪 陈晓东[1] YANG Rong-hua;RUAN Shu-bin;LIN Ze-peng(Department of Burn Plastic Wound Repair Surgery,Foshan First People’s Hospital,Foshan 528000,China)

机构地区：[1]广东省佛山市第一人民医院烧伤整形创面修复外科,528000

出　　处：《中国实用医药》2020年第20期47-49,共3页China Practical Medicine

摘　　要：目的观察富血小板血浆(PRP)治疗糖尿病足难愈性创面的临床疗效。方法38例糖尿病足患者,根据治疗方法不同分为实验组(22例)和对照组(16例)。对照组采用常规方法治疗,实验组在对照组基础上联合PRP治疗。比较两组治疗后1、2、3周的创面愈合率、愈合时间、截肢(趾)率及创面复发率。结果治疗后1、2、3周,实验组创面愈合率分别为(26.6±5.5)%、(58.4±8.4)%和(93.6±9.2)%,对照组分别为(21.8±5.7)%、(38.7±6.8)%和(62.5±9.3)%。治疗后1周,两组创面愈合率比较差异无统计学意义(P>0.05)。治疗后2、3周,实验组创面愈合率显著高于对照组,差异均有统计学意义(P<0.05)。实验组平均愈合时间(18.2±3.4)d明显短于对照组的(28.6±6.8)d,差异具有统计学意义(P<0.05)。实验组截肢(趾)率为22.7%(5/22),明显低于对照组的56.3%(9/16),差异具有统计学意义(P<0.05)。除3例脱访(实验组2个,对照组1个),其余患者随访6个月。实验组复发率为13.6%(3/20),明显低于对照组的46.7%(7/15),差异具有统计学意义(P<0.05)。结论PRP可以有效的促进糖尿病足难愈性创面的愈合,缩短住院时间,降低截肢(趾)率,减少复发率,明显改善患者的生活质量。Objective To observe the clinical efficacy of platelet-rich plasma(PRP)on diabetic foot refractory wounds.Methods A total of 38 diabetic foot patients were divided into experimental group(22 cases)and control group(16 cases)by different treatment methods.The control group was treated by conventional therapy,and the experimental group was treated by PRP on the basis of the control group.The wound healing rate 1,2 and 3 weeks after treatment,healing time,amputation(toe)rate and wound recurrence rate were compared between the two groups.Results 1,2 and 3 weeks after treatment,the wound healing rate of the experimental group were(26.6±5.5)%,(58.4±8.4)%and(93.6±9.2)%,which were(21.8±5.7)%,(38.7±6.8)%and(62.5±9.3)%respectively.1 week after treatment,there was no statistically significant difference in wound healing rate between the two groups(P>0.05).2 and 3 weeks after treatment,the wound healing rate of the experimental group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The average healing time(18.2±3.4)d of the experimental group was obviously shorter than that of the control group(28.6±6.8)d,and the difference was statistically significant(P<0.05).The amputation(toe)rate of the experimental group was 22.7%(5/22),which was obviously lower than that of the control group 56.3%(9/16),and the difference was statistically significant(P<0.05).Except for 3 patients(2 cases in the experimental group and 1 case in the control group)lost to follow-up,the remaining patients were followed up for 6 months.The recurrence rate of the experimental group was 13.6%(3/20),which was obviously lower than that of the control group 46.7%(7/15),and the difference was statistically significant(P<0.05).Conclusion PRP can effectively promote the healing of diabetic foot refractory wounds,shorten the hospitalization time,reduce the amputation(toe)rate,reduce the recurrence rate,and significantly improve the patient’s quality of life.

关 键 词：糖尿病足 富血小板血浆 难愈性创面 

分 类 号：R587.2[医药卫生—内分泌]