奥曲肽联合肠内营养治疗重症胰腺炎临床疗效及对患者血流动力学预后的影响  

The clinical effect of octreotide combined with enteral nutri-tion in the treatment of severe pancreatitis and its influence on the hemodynamic prognosis of patients

作　　者：高俊[1] 王学祥[1] 张一飞 王正茂[1] Gao Jun;Wang Xuexiang;Zhang Yifei;Wang Zhengmao(Nanyang Second People's Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市第二人民医院,河南南阳473000

出　　处：《临床心身疾病杂志》2020年第4期33-35,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨奥曲肽联合肠内营养治疗重症胰腺炎临床疗效及对患者血流动力学、预后的影响.方法将60例重症胰腺炎患者按照随机数字表法分为观察组与对照组,各30例.两组均给予奥曲肽治疗,观察组联合肠内营养治疗,观察7d.比较两组临床疗效、治疗前后血流动力学指标水平及预后情况.结果 观察组治疗总有效率显著高于对照组(P<0.05).治疗后观察组平均动脉压、中心静脉压水平显著高于治疗前(P<0.01),心率水平显著低于治疗前(P<0.01),对照组平均动脉压水平显著高于治疗前(P<0.05),心率水平显著低于治疗前(P<0.05),观察组较对照组变化更显著(P<0.01).观察组感染率显著低于对照组(P<0.05),两组多器官功能衰竭发生率及病死率比较差异无统计学意义(P>0.05).结论奥曲肽联合肠内营养治疗重症胰腺炎患者疗效显著,可有效调控患者血流动力学指标,改善预后.Objective To investigate the clinical efficacy of octreotide combined with enteral nutrition in the treatment of severe pancreatitis and its influence on the hemodynamic prognosis of patients.Methods Sixty patients with severe pancreatitis were divided into observation group and control group according to random number table method,30 cases each.Both groups were given octreotide therapy,and the observa­tion group combined with enteral nutrition therapy to compare the clinical efficacy,hemodynamic index levels and prognosis of the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the average ar­terial pressure and central venous pressure in the observation group were significantly higher than before treatment(P<0.01),and the heart rate was significantly lower than before treatment(P<0.01),the average arterial pressure level of the control group was significantly higher than before treatment(P<0.05),the heart rate level was significantly lower than before treatment(P<0.05),the observation group changed more significantly than the control group(P<0.01).The infection rate in the observation group was significantly lower than that in the control group(P<0.05),and there was no statistically sig­nificant difference in the incidence and mortality of multiple organ failure between the two groups(P>0.05).Conclusions Octreotide combined with enteral nutrition is effective in the treatment of severe pan­creatitis patients,which can effectively improve the level of hemodynamic indicators and improve the prog­nosis of patients.

关 键 词：重症胰腺炎 奥曲肽 肠内营养 血流动力学 预后 

分 类 号：R657.5[医药卫生—外科学]