胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良疗效观察  

Gastrointestinal medicine combined with escitalopram oxalate in the treatment of refractory functional dyspepsia

作　　者：陈叶青 周国华 周红宇 雷耀耀 谭晓华 韩龙 刘田田 Chen Yeqing;Zhou Guohua;Zhou Hongyu;Lei Yaoyao;Tan Xiaohua;Han Long;Liu Tiantian(Joint Logistics Support Unit 922 Hospital,Hengyang 421002,Hunan,China)

机构地区：[1]中国人民解放军联勤保障部队第九二二医院,湖南衡阳421002

出　　处：《临床心身疾病杂志》2020年第4期162-164,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良的临床疗效.方法将82例难治性功能性消化不良患者按照治疗方法分为观察组42例与对照组40例,两组均给予泮托拉唑钠肠溶片及马来酸曲美布汀分散片治疗,观察组在此基础上联合草酸艾司西酞普兰片治疗,治疗8周.比较两组临床疗效,治疗前后采用汉密顿焦虑量表及汉密顿抑郁量表评定两组焦虑及抑郁情绪.每2周进行血、尿常规,肝肾功能和心电图检查,比较两组不良反应发生情况.结果 观察组治疗总有效率显著高于对照组(P<0.01).治疗8周末两组汉密顿焦虑量表及汉密顿抑郁量表评分均较治疗前显著下降(P<0.01),观察组较对照组下降更显著(P<0.01).治疗前后两组血、尿常规,肝肾功能及心电图均无明显改变,两组不良反应发生率比较差异无统计学意义(P>0.05).结论胃肠药物联合草酸艾司西酞普兰治疗难治性功能性消化不良疗效较好,能显著改善患者的焦虑、抑郁状态,不良反应轻微,值得推广应用.Objective To observe the curative effect of gastrointestinal medicine combined with escitalopram oxalate in the treatment of refractory functional dyspepsia.Methods 82 patients with refractory functional dyspepsia were divided into observation group(42 cases)and control group(40 cases)according to the treatment method.Both groups were given pantoprazole sodium enteric-coated tablets and trimebutine maleate dispersible tablets.The observation group combined with escitalopram oxalate tablets for 8 weeks.The clinical efficacy of the two groups was compared.Before and after treatment,HAMA and HAMD were used to assess anxiety and depression.Blood and urine routine,liver and kidney function and electrocardiogram were performed every 2 weeks.Compare the occurrence of adverse reactions between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.01).After 8 weeks of treatment,the HAMA and HAMD scores of the two groups were significantly lower than before treatment(P<0.01),and the observation group was more significantly lower than the control group(P<0.01).There were no significant changes in blood and urine routines,liver and kidney functions and electrocardiogram before and after treatment in the two groups,and there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Gastrointestinal medicine combined with escitalopram oxalate have a better curative effect on refractory functional dyspepsia,and can significantly improve patients'anxiety and depression status.The side effects are mild,and it is worth popularizing and applying.

关 键 词：难治性功能性消化不良 草酸艾司西酞普兰 焦虑 抑郁 汉密顿焦虑量表 汉密顿抑郁量表 

分 类 号：R333.5[医药卫生—人体生理学]