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作 者:Tao Liu Qing-Yuan Qin Jiang-Xue Qu Hai-Yan Wang Jie Yan
机构地区:[1]Department of Obstetrics and Gynecology,Center for Reproductive Medicine,Peking University Third Hospital,Beijing 100191,China [2]Key Laboratory of Assisted Reproduction,Ministry of Education,Beijing 100191,China [3]Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction,Beijing 100191,China
出 处:《Chinese Medical Journal》2020年第14期1711-1718,共8页中华医学杂志(英文版)
基 金:This work was supported by grants from the National Key Technology R&D Program of China(Nos.2017YFC1002002 and 2018YFC1004001);the National Science Foundation of China(No.81571386);the Special Research Project of Chinese Capital Health Development(No.2018-2-4095).
摘 要:Mammalian follicles are composed of oocytes,granulosa cells,and theca cells.Theca cells form in the secondary follicles,maintaining follicular structural integrity and secreting steroid hormones.Two main sources of theca cells exist:Wilms tumor 1 positive(Wt1+)cells native to the ovary and Gli1+mesenchymal cells migrated from the mesonephros.Normal folliculogenesis is a process where oocytes,granulosa cells,and theca cells constantly interact with and support each other through autocrine and paracrine mechanisms.The proliferation and differentiation of theca cells are regulated by oocyte-derived factors,including growth development factor 9 and bone morphogenetic protein 15,and granulosa cell-derived factors,including desert hedgehog,Indian hedgehog,kit ligand,insulin-like growth factor 1,as well as hormones such as insulin and growth hormones.Current research on the origin of theca cells is limited.Identifying the origin of theca cells will help us to systematically elaborate the mechanisms of follicular formation and development.
关 键 词:Theca cell Hedgehog pathway Growth development factor 9 Bone morphogenetic protein 15 TGF-b superfamily Kit ligand
分 类 号:R321.1[医药卫生—人体解剖和组织胚胎学]
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