骨髓间充质干细胞在女性不孕症治疗中的研究进展  

Research progress of bone marrow mesenchymal stem cells in treatment of female infertility

作　　者：王欣 刘琳 吕芳 WANG Xin;LIU Lin;LYU Fang(Reproductive Medicine Center,Department of Obstetrics&Gynecology,Clinical Medical College,Yangzhou University,Northern Jiangsu People’s Hospital,Yangzhou 225001;Department of College of Basic Medical Science,Luohe Medical College,Luohe 462002;Reproductive Medicine Center,the Second Affiliated Hospital of Soochow University,Suzhou 215000)

机构地区：[1]扬州大学临床医学院,江苏省苏北人民医院妇产科生殖医学中心,扬州225001 [2]漯河医学院基础医学院,漯河462002 [3]苏州大学附属第二医院妇产科生殖中心,苏州215000

出　　处：《生殖医学杂志》2020年第8期1110-1114,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金项目(81601343);国家科技基础性工作专项(2013FY110521);江苏省六大人才高峰项目(WSW-197);江苏省青年医学人才项目(QNRC2016345)。

摘　　要：女性不孕的原因主要有排卵障碍、输卵管疾病及内膜相关疾病。研究证明骨髓细胞在妊娠中非常重要,骨髓祖细胞能够成为胎盘蜕膜细胞参与维持成功妊娠。骨髓间充质干细胞因为其优良的生物学特性,近年来广泛应用于再生医学和组织修复,在不孕相关疾病如多囊卵巢综合征、原发性卵巢功能不全、输卵管疾病、子宫内膜疾病的治疗中也有研究,为疑难不孕症的治疗提供了新思路。现就骨髓间充质干细胞在女性不孕相关疾病中的治疗做一简要综述。The main causes of female infertility include ovulation failure,fallopian tubal disease and endometrial disease.Studies have shown that bone marrow cells are very important in pregnancy,and bone marrow progenitor cells can become placental decidual cells and participate in maintaining a successful pregnancy.Bone marrow mesenchymal stem cells(BMSCs)with excellent biological properties are widely applied in regenerative medicine and tissue repair.BMSCs were studied in female infertility related diseases,such as polycystic ovary syndrome,primary ovarian insufficiency,fallopian tubal disease and endometrial disease,which provide new ideas for the treatment of difficult infertility.Here is a brief review of the treatment of BMSCs in female infertility related diseases.

关 键 词：BMSCS 不孕症 多囊卵巢综合征 原发性卵巢功能不全 ASHERMAN综合征 输卵管炎 

分 类 号：R711.6[医药卫生—妇产科学]