不同时间应用奥司他韦治疗儿童流行性感冒的临床效果  

Clinical effect of different timing of oseltamivir on children’s influenza

作　　者：谢若欣[1] 谢春奇[1] 袁梁玉[1] XIE Ruo-xin;XIE Chun-qi;YUAN Liang-yu(Department of Pediatrics,Zhuhai Maternal and Child Health Hospital,Zhuhai 519000,China)

机构地区：[1]珠海市妇幼保健院儿科,519000

出　　处：《中国现代药物应用》2020年第16期1-3,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨不同时间应用奥司他韦治疗儿童流行性感冒(流感)的临床效果。方法80例流感患儿,按照随机数字表法分为48 h内组与48~96 h组,各40例。48 h内组在患儿出现症状后48 h内应用奥司他韦治疗,48~96 h组在患儿出现症状后48~96 h采用奥司他韦治疗。对比两组患儿临床症状消失时间;治疗效果;不良反应发生情况。结果48 h内组的体温恢复正常时间(1.65±0.91)d、咳嗽消失时间(1.73±1.19)d、鼻塞流涕消失时间(1.72±1.27)d及疲倦纳差消失时间(1.63±1.14)d均短于48~96 h组的(3.58±1.89)、(3.93±2.76)、(3.56±2.35)、(3.66±2.90)d,差异均有统计学意义(P<0.05)。48 h内组的治疗总有效率97.50%高于48~96 h组的85.00%,差异有统计学意义(P<0.05)。48 h内组不良反应发生率7.50%与48~96 h组的7.50%对比,差异无统计学意义(P>0.05)。结论流感症状出现48 h内早期应用比48~96 h晚期应用奥司他韦治疗儿童流感可更快缓解流感症状,明显缩短病程、疗效显著、未增加不良反应。在临床流感症状出现后可尽早于48 h内使用奥司他韦抗病毒治疗。Objective To discuss the clinical effect of different timing of oseltamivir on children’s influenza.Methods A total of 80 children with influenza were divided into 48 h group and 48-96 h group by random numerical table,with 40 cases in each group.48 h group was treated with oseltamivir within 48 h after symptoms of influenza in children,and 48-96 h group was treated with oseltamivir within 48-96 h after symptoms of influenza.The disappearance time of clinical symptoms,therapeutic effect and occurrence of adverse reactions were compared between the two groups.Results The time of temperature recovering normal,cough disappearance time,disappearance time of nasal congestion and runny nose and disappearance time of fatigue and poor appetite of 48 h group were(1.65±0.91),(1.73±1.19),(1.72±1.27)and(1.63±1.14)d,which were shorter than those of 48-96 h group(3.58±1.89),(3.93±2.76),(3.56±2.35)and(3.66±2.90)d,and the difference was statistically significant(P<0.05).The total effective rate of treatment 97.50%of 48 h group was higher than that of 48-96 h group 85.00%,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 7.50%of 48 h group had no statistically significant difference compared with that of 48-96 h group 7.50%(P>0.05).Conclusion The early application of oseltamivir in 48 h after symptoms of influenza can relieve influenza symptoms faster,significantly shorten the course of disease,significantly improve the efficacy with no increased adverse reactions.Oseltamivir can be used within 48 h after symptoms of influenza.

关 键 词：早期 奥司他韦 流行性感冒 儿童 

分 类 号：R725.1[医药卫生—儿科]