老年肌少症的危险因素分析及与NAFLD的关系研究  

Analysis of risk factors for senile sarcopenia and its relationship with NAFLD

作　　者：郝瑞瑞[1] 王欢[1] 王海燕[1] 汤文 卢玉[1] HAO Rui-rui;WANG Huan;WANG Hai-yan(Internal Medicine Department of Medical Healthcare Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院医疗保健中心内科,北京100050

出　　处：《临床和实验医学杂志》2020年第15期1588-1591,共4页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金(编号:81771860)。

摘　　要：目的探讨老年肌少症的危险因素及与非酒精性脂肪性肝病(NAFLD)的关系。方法回顾性选取2017年1月至2019年12月首都医科大学附属北京友谊医院医疗保健中心门诊和住院的体检人群共216例,收集这些人群的人口学资料、病史、实验室指标,将上述两组人群分为肌少症组(n=121)和非肌少症组(n=95)。比较两组人群的临床资料、NAFLD的发病率,采用Logistic回归性分析评价老年肌少症的相关危险因素。结果肌少症组人群的年龄、性别、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、C反应蛋白(h-CRP)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平与非肌少症组比较,差异无统计学意义(P>0.05);而肌少症组人群的骨含量、25-羟维生素D、体重指数(BMI)明显低于非肌少症组;Logistic回归性分析显示,年龄、骨含量、25-羟维生素D、BMI与老年患者肌少症的发生有负相关回归关系。肌少症组人群的NAFLD患病率(52.1%)明显高于非肌少症组(33.7%),差异具有统计学意义(P<0.05)。结论年龄、骨含量、25-羟维生素D、BMI是老年患者肌少症的危险因素。肌少症组患者的NAFLD的患病率明显高于非肌少症组,提示两种疾病之间有一定的联系。Objective To investigate the risk factors for senile sarcopenia and its relationship with non-alcoholic fatty liver disease(NAFLD).Methods The retrospective study selected 216 patients who received inpatient or outpatient physical examination in the Internal Medicine Department Medical Healthcare Center,Beijing Friendship Hospital Medical,Capital Medical University from January 2017 to December2019.The demographic data,medical history,and laboratory parameters of these cases were collected.The patients were divided into the sarcopenia group(n = 121) and the non-sarcopenia group(n = 95).The clinical data and the prevalence of NAFLD were compared between the two groups.Logistic regression analysis was used to analyze the relevant risk factors for senile sarcopenia.Results There were no significant differences in age,gender,glutamic oxalacetic transaminase(AST),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),hypersensitive C-reactive protein(h-CRP),free triiodothyronine(FT3),free thyroxine(FT4),and thyroid stimulating hormone(TSH) levels of the sarcopenia group and the non-sarcopenia group(P >0.05).Bone material density(BMD),25-hydroxyvitamin D and body mass index(BMI) in the sarcopenia group were significantly lower than those in the non-sarcopenia group.Logistic regression analysis showed that age,bone material density,25-hydroxyvitamin D,BMI had a negative correlation with the incidence of sarcopenia in elderly patients.The prevalence of NAFLD in the sarcopenia group(52.1%) was significantly higher than that in the non-sarcopenia group(33.7%),and the difference was statistically significant(P< 0.05).Conclusion Age,bone material density,25-hydroxyvitamin D,and BMI are risk factors for sarcopenia in elderly patients.The prevalence of NAFLD in the sarcopenia group was significantly higher than that in the non-sarcopenia group,suggesting a certain link between the two diseases.

关 键 词：老年人 肌少症 非酒精性脂肪性肝 25-羟维生素D 

分 类 号：R685[医药卫生—骨科学] R575.5[医药卫生—外科学]