内皮细胞糖代谢在血管发育中的作用  

Role of endothelial cell glucose metabolism in vascular development

作　　者：王媛[1] 王钧左 严溢泉 葛昕 李伟[2] 赵星成[1] WANG Yuan;WANG Jun-zuo;YAN Yi-quan;GE Xin;LI Wei;ZHAO Xing-cheng(Department of Aerospace Medical Training,Department of Aerospace Physiology,Fourth Military Medical University,Xi'an 710032,China;The Fifth Flight Training Regiment,Primary Flight Training Base of Air Force Aviation University,Zibo 255300,China)

机构地区：[1]第四军医大学航空航天医学训练教研室,航空航天生理学教研室,陕西西安710032 [2]空军航空大学初级飞行训练基地第五训练团,山东淄博255300

出　　处：《中国病理生理杂志》2020年第8期1515-1520,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81803098);军队后勤科研计划重大项目(No.AKJ18J001);第四军医大学航空航天一流学科建设优秀本科生导师制培养专项基金(No.2019YXBKS09)。

摘　　要：内皮细胞代谢在健康维护和疾病发生中发挥着重要作用,其主要的代谢通路包括糖酵解、脂肪酸氧化和氨基酸代谢,都在血管发育进程和结构的形成中有着重要的作用。在多种血管相关疾病如动脉粥样硬化、糖尿病、视网膜新生血管疾病和肿瘤中,都伴随不同程度的内皮细胞代谢紊乱。深入理解内皮细胞代谢紊乱在这些疾病中的重要作用对于以代谢为靶点的治疗格外重要。As an important organ in the body,blood vessels transport oxygen and nutrients to the tissues of the body. Endothelial cells are layers of cells lined with blood vessels whose metabolism is involved in regulating multiple links of vascular development and vascular diseases. Glucose metabolism provides the main energy for endothelial cells,and changes in glucose metabolism regulation affect vascular development and even lead to various diseases. Recently,strategies have been proposed to target endothelial cell metabolism for the treatment of vascular diseases. This article reviews the role of endothelial cell glucose metabolism in vascular development and vascular diseases in recent years.

关 键 词：内皮细胞 糖代谢 血管生成 动脉粥样硬化 肿瘤 糖尿病视网膜病变 

分 类 号：R543[医药卫生—心血管疾病] R363[医药卫生—内科学]