Effect of Vigna radiata, Tamarix ramosissima and Carthamus lanatus extracts on Leishmania major and Leishmania tropica: An in vitro study  

作　　者：Alisha Akya Roya Chegene Lorestani Hossein Zhaleh Fatemeh Nemati Zargaran Keyghobad Ghadiri Mosayeb Rostamian 

机构地区：[1]Infectious Diseases Research Center,Health Institute,Kermanshah University of Medical Sciences,Kermanshah 6714415333,Iran [2]Substance Abuse Prevention Research Center,Health Institute,Kermanshah University of Medical Sciences,Kermanshah 6714415333,Iran

出　　处：《Chinese Herbal Medicines》2020年第2期171-177,共7页中草药（英文版）

基　　金：supported by Kermanshah University of Medical Sciences(Funding No:97318)。

摘　　要：Objective:Current therapy strategies of leishmaniasis have some problems such as high cost,toxicity and side effects.Plant extracts can be a source of drugs to control leishmaniasis.In this study,the effect of hydroalcoholic and chloroformic extracts of Vigna radiata,Tamarix ramosissima,and Carthamus lanatus on Leishmania major and L.tropica was studied.Methods:The plant samples were collected from west of Iran and their extracts were prepared.Antipromastigote activity assay of all extracts was done using tetrazolium-dye assay.Results:Only high concentrations of V.radiata and C.lanatus were able to inhibit Leishmania,while both high and low concentrations of T.ramosissima had antileishmanial effect.No difference was observed between hydroalcoholic with chloroformic extract of each plant.Conclusion:Altogether,the results revealed the antileishmanial activity of T.ramosissima extracts against L.major and L.tropica,indicating its potential as an antileishmanial agent.

关 键 词：antileishmanial agent cutaneous leishmaniasis Carthamus lanatus L Leishmania major Leishmania tropica Tamarix ramosissima Lcdcb Vigna radiata(Linn.)Wilczek 

分 类 号：R285.5[医药卫生—中药学]