普萘洛尔与甲巯咪唑联合治疗对甲亢患者血清PTH OCN ALP及血钙血磷水平的影响  

Effects of Propranolol Combined with Methimazole on Serum PTH OCN ALP Ca and P Levels of Patients with Hyperthyroidism

作　　者：徐文 陈朝聪 徐文娟 XU Wen;CHEN Chaocong;XU Wenjuan(Danzhou People's Hospital, Hainan Danzhou 571700, China)

机构地区：[1]海南省儋州市人民医院药剂科,海南儋州571700

出　　处：《河北医学》2020年第8期1304-1307,共4页Hebei Medicine

基　　金：海南省卫生计生行业科研项目,(编号:1605320245A2001)。

摘　　要：目的:分析普萘洛尔与甲巯咪唑联合治疗对甲状腺功能亢进(甲亢)患者血清甲状旁腺素(PTH)、骨钙素(OCN)、碱性磷酸酶(ALP)及血钙(Ca)、血磷(P)水平的影响。方法:选取我院2017年12月至2018年12月收治的200例甲亢患者为对象,采用简单随机法将其分为观察组(n=100)和对照组(n=100),对照组给予甲巯咪唑治疗,观察组给予普萘洛尔与甲巯咪唑联合治疗。比较两组的临床疗效、血清PTH、OCN、ALP和Ca、P水平的变化、不良反应发生率及复发率。结果:治疗后观察组血清PTH、Ca水平均显著高于对照组,OCN、ALP、P水平均显著低于对照组(P<0.05);治疗后观察组总有效率为88.00%,显著高于对照组的70.00%(P<0.05);治疗后观察组不良反应率为6.67%,显著低于对照组的24.44%(P<0.05);观察组复发率为3.00%,显著低于对照组11.00%(P<0.05)。结论:普萘洛尔与甲巯咪唑联合治疗甲亢患者的临床疗效显著,可降低血清OCN、ALP、P水平,升高PTH、Ca水平,值得进一步推广使用。Objective:To analyze the effects of propranolol combined with methimazole on serum parathyroid hormone(PTH),osteocalcin(OCN),alkaline phosphatase(ALP),calcium(Ca)and phosphorus(P)levels in patients with hyperthyroidism.Methods:A total of 200 patients with hyperthyroidism who were admitted to the hospital from December 2017 to December 2018 were selected as subjects.They were divided into the observation group(n=100)and the control group(n=100)with simple random method.The control group was treated with methimazole while the observation group was treated with propranolol combined with methimazole.The clinical curative effect,serum PTH,OCN,ALP,Ca and P levels,the incidence of adverse reactions and recurrence rate were compared between the two groups.Results:After treatment,the levels of serum PTH and Ca in the observation group were significantly higher than those in the control group.The levels of OCN,ALP and P were significantly lower than those in the control group(P<0.05).The total effective rate of the observation group after treatment was significantly higher than that of the control group(88.00%vs 70.00%)(P<0.05).The incidence of adverse reactions in the observation group after treatment was significantly lower than that in the control group(6.67%vs 24.44%)(P<0.05).The recurrence rate of the observation group was 3.00%,which was significantly lower than that of the control group(11.00%)(P<0.05).Conclusion:The clinical curative effect of propranolol combined with methimazole is obvious in the process of hyperthyroidism treatment.The comprehensive treatment can reduce the levels of serum OCN,ALP and P,and increase the levels of PTH and Ca.

关 键 词：甲亢 普萘洛尔 甲巯咪唑 

分 类 号：R58[医药卫生—内分泌]