肌酸激酶乳酸脱氢酶在新生儿胆红素脑病患儿血清中的表达及临床意义  

Expressions and Clinical Significance of Creatine Kinase and Lactate Dehydrogenase in Serum of Beonatal Bilirubin Encephalopathy

作　　者：陈秀霞[1] 庄超 王彩霞[1] 张美英[1] 徐璐璐 CHEN Xiuxia(Qingdao Municipal Hospital of Shandong Province, Shandong Qingdao 266000, China)

机构地区：[1]山东省青岛市市立医院儿科,山东青岛266000 [2]山东省青岛市妇女儿童医院血液科,山东青岛266000

出　　处：《河北医学》2020年第8期1376-1380,共5页Hebei Medicine

基　　金：山东省医药卫生科技发展计划项目,(编号:2017WS0194)。

摘　　要：目的:探讨血清肌酸激酶(CK)、乳酸脱氢酶(LDH)在新生儿胆红素脑病患儿血清中的表达及临床意义。方法:选取2017年1月至2019年10月于青岛市市立医院就诊的高胆红素血症患儿120例,其中符合胆红素脑病诊断标准的患儿67例为病例组,非胆红素脑病患儿53例为对照组。采用酶学速率法检测两组患儿血清CK、LDH水平;采用偶氮咖啡因比色法检测血清总胆红素(TBIL)水平;采用Pearson相关法分析胆红素脑病患儿血清CK、LDH水平分别与血清TBIL水平、BAEP的相关性;并分析影响新生儿胆红素脑病发生的相关因素。结果:病例组患儿血清总胆红素峰值、酸中毒比例、血清TBIL水平及BAEP显著高于对照组(P<0.05);病例组患儿血清CK、LDH水平均显著高于对照组(P<0.05);Pearson法分析结果显示,新生儿胆红素脑病患儿血清CK、LDH水平与血清TBIL水平、BAEP均呈正相关(P<0.001);Logistic回归分析结果显示,影响新生儿发生胆红素脑病的危险因素主要有总胆红素峰值高、酸中毒、及血清CK、LDH水平(P<0.05)。结论:CK、LDH在新生儿胆红素脑病患儿血清中水平升高,与患儿血清TBIL水平、BAEP具有一定相关性,是新生儿发生胆红素脑病的危险因素,可能作为评估新生儿发生胆红素脑病的参考指标。Objective:To investigate the expressions and clinical significance of creatine kinase(CK)and lactate dehydrogenase(LDH)in serum of neonatal bilirubin encephalopathy.Methods:120 children with hyperbilirubinemia who were hospitalized in Qingdao Municipal Hospital from January 2017 to October 2019 were selected,among them,67 children with bilirubin encephalopathy were in the case group and 53 children without bilirubin encephalopathy were in the control group.The levels of serum CK and LDH were measured by enzymology rate method;the level of serum total bilirubin(TBIL)was measured by caffeine azo colorimetry;Pearson correlation method was used to analyze the correlations between the levels of serum CK,LDH and level of serum TBIL,BAEP;and the related factors of neonatal bilirubin encephalopathy were analyzed.Results:The peak value of serum total bilirubin,the proportion of acidosis,the level of serum TBIL and BAEP in the case group were significantly higher than those in the control group(P<0.05);the levels of serum CK and LDH in the case group were significantly higher than those in the control group(P<0.05);the results of Pearson analysis showed that the levels of serum CK and LDH were positively correlated with level of serum TBIL and BAEP(P<0.001);and the results of logistic regression analysis showed that the main risk factors of bilirubin encephalopathy were high peak value of total bilirubin,acidosis,serum CK and LDH levels(P<0.05).Conclusion:The levels of CK and LDH in the serum of neonatal bilirubin encephalopathy are increased,which are certainly related to the level of serum TBIL and BAEP.They are risk factors of neonatal bilirubin encephalopathy and may be used as reference indexes to evaluate neonatal bilirubin encephalopathy.

关 键 词：肌酸激酶 乳酸脱氢酶 新生儿 胆红素脑病 

分 类 号：R722.1[医药卫生—儿科]