脐血锰浓度和1岁婴儿体重的关系:基于山东莱州湾出生队列研究  

Relationship between umbilical serum manganese level and weight of one-year-old infants: Based on Laizhou Wan Birth Cohort Study

作　　者：余晋霞 卢婍 张妍 姚谦 施蓉 高宇 YU Jin-xia;LU Qi;ZHANG Yan;YAO Qian;SHI Rong;GAO Yu(Department of Environmental Health,School of Public Health,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院公共卫生学院环境与健康系,上海200025

出　　处：《环境与职业医学》2020年第7期672-678,共7页Journal of Environmental and Occupational Medicine

基　　金：上海市科委自然科学基金(17ZR1415800);国家自然科学基金面上项目(81773387);国家自然科学基金青年项目(81602823)。

摘　　要：[背景]大量研究表明锰可以对人体的生长发育产生影响。婴幼儿阶段是生长发育的关键期,更易受锰暴露的毒性影响。[目的]探讨脐血锰浓度与1岁婴儿体重的关系。[方法]基于山东莱州湾出生队列,将183例同时完成问卷调查及脐带血检测的母子对纳入研究。通过问卷调查一般人口学特征和1岁婴儿膳食信息,测量其身高、体重,并测定脐血锰、铅、砷和铁的质量浓度(后称浓度)。按锰暴露水平对数值的四分位数将研究对象分为四组(Q1~Q4),描述不同组间的一般人口学特征。采用单因素回归分析研究1岁婴儿体重的影响因素。在校正孕前体质量指数(BMI)、家庭月收入、产次、出生体重、婴儿性别、1岁婴儿主食摄入频次及脐血铅、铁和砷元素后,采用广义线性模型分析脐血锰浓度对1岁婴儿体重的影响,并进一步研究了不同性别间该影响的差异。[结果]183例孕妇年龄为(27.90±4.61)岁,孕前BMI为(21.72±3.04)kg·m-2。其中132例为初产妇(72.1%),136例孕妇无主动或被动吸烟情况(74.3%)。大多数1岁婴儿经常摄入主食(83.6%)。1岁婴儿体重为(10.55±1.15)kg,身高为(76.97±2.71)cm。孕妇人口学特征在脐血锰浓度Q1~Q4组间差异均无统计学意义(P>0.05),1岁婴儿体重和身高在脐血锰浓度Q1~Q4组间差异具有统计学意义(F=4.111,P=0.008;F=2.717,P=0.046)。锰、铅、铁和砷在脐血的检出率分别为82.5%(151/183)、85.8%(157/183)、99.5%(182/183)和79.8%(146/183)。脐血锰、脐血铅、脐血铁和脐血砷中位数浓度分别为106.1μg·L-1、36.3μg·L-1、462.7 mg·L-1、6.4μg·L-1。1岁婴儿体重与脐血锰浓度(P=0.005)、脐血铅浓度(P=0.030)、1岁婴儿主食摄入频次(P<0.05)以及婴儿性别(P<0.001)的关联具有统计学意义。脐血锰浓度每增加一个对数浓度,1岁婴儿体重平均减少0.10 kg(95%CI:-0.12^-0.07,P=0.021),Q2组1岁婴儿体重平均减少0.68 kg(95%CI:-1.11^-0.26,P=0.002),Q3和Q4组�[Background]A large number of studies have shown that manganese can affect the growth and development of human body.The infant stage is a critical period of rapid growth and development,and it is more susceptible to the toxic effects due to manganese exposure.[Objective]The study is designed to investigate the relationship between umbilical serum manganese level and the weight of one-year-old infants.[Methods]The present study was based on the Laizhou Wan Birth Cohort Study.A total of 183 mother-child pairs were finally enrolled,who completed questionnaires and umbilical cord blood measurement.The participants’demographic characteristics and one-year-old infants’diet were collected,and infants’height,weight,and umbilical cord blood levels of manganese,plead,arsenic,and iron were measured.The study subjects were divided into four groups(Q1-Q4)according to quartiles of manganese exposure level,and the general demographic characteristics were described.Univariate regression analysis was used to study the influencing factors of infants’weight at one year old.After adjusting for pregnant woman’s body mass index(BMI),family monthly income,parity,infant’s weight at birth,infant’s sex,infant’s staple food intake frequency,lead,iron,and arsenic in umbilical cord blood,generalized linear model was used to analyze the relationship between umbilical blood manganese level and the weight of one-year-old infants,and the effect on different genders was further studied.[Results]The average age of the 183 pregnant women was(27.90±4.61)years old,and the pre-pregnancy BMI was(21.72±3.04)kg·m-2.Among them,132 pregnant women were primiparas(72.1%),and 136 pregnant women had no active or passive smoking behaviors(74.3%).Most infants of one year old often consumed staple foods(83.6%).The one-year-old infants weighed(10.55±1.15)kg,and was(76.97±2.71)cm in height.The demographic characteristics of pregnant women showed no significant differences among Q1 to Q4 umbilical cord blood manganese concentration groups(P>0.05

关 键 词：微量元素 锰 体重 脐带血 出生队列研究 

分 类 号：R174[医药卫生—妇幼卫生保健]