血管紧张素-(1-7)与脂质代谢研究进展  

Angiotensin-(1-7)and Lipid Metabolism

作　　者：张锦霞 梁斌[2] 杨志明[2] ZHANG Jinxia;LIANG Bin;YANG Zhiming(Shanxi Medical University Graduate School,Taiyuan 030000,Shanxi,China;Department of Cardiology,The Second Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi,China)

机构地区：[1]山西医科大学研究生院,山西太原030000 [2]山西医科大学第二医院心血管内科,山西太原030001

出　　处：《心血管病学进展》2020年第7期745-748,共4页Advances in Cardiovascular Diseases

基　　金：山西省优秀青年基金(201901D211504);山西省自然基金青年基金(201601D021154);山西省高等学校青年学科带头人基金(2017011)。

摘　　要：脂质代谢是人体主要代谢之一,包括脂肪代谢、胆固醇代谢和磷脂代谢。脂质代谢紊乱主要为甘油三酯、总胆固醇、低密度脂蛋白胆固醇升高,以及高密度脂蛋白胆固醇降低,是引发急性冠脉综合征和脑卒中等心脑血管疾病的重要原因。血管紧张素-(1-7)作为肾素-血管紧张素系统中一种新的生物活性肽,近年来被国内外学者研究发现,其在降压、抗心肌纤维化、抗心律失常和改善动脉粥样硬化等心血管疾病中发挥作用,同时研究发现,血管紧张素-(1-7)通过抑制脂肪合成,促进脂肪分解,改善脂肪变性和调节胆固醇转运等参与脂质代谢。现就血管紧张素-(1-7)与脂质代谢的研究进展做一综述。Lipid metabolism is one of the main metabolisms in human body,including fat metabolism,cholesterol metabolism,phospholipid metabolism.Lipid metabolism disorder are mainly triglyceride,total cholesterol,low-density lipoprotein cholesterol increased and high-density lipoprotein cholesterol decreased,which is an important cardiovascular and cerebrovascular diseases such as acute coronary syndrome and stroke.As a new bio-active peptide in the renin-angiotensin system,angiotensin-(1-7)has been studied by researchers at home and abroad in recent years,and it has been found to play a role in cardiovascular diseases such as bring high blood pressure down,anti-myofibrosis,anti-arrhythmia,and improvement of atherosclerosis.Angiotensin-(1-7)contribute to lipid metabolism by inhibiting fat synthesis,promoting fat breakdown,improving steatosis and regulating cholesterol transport.The progress of angiotensin-(1-7)and lipid metabolism is reviewed.

关 键 词：血管紧张素-(1-7) 脂质代谢 动脉粥样硬化 

分 类 号：R333[医药卫生—人体生理学]