中医药改善乙型肝炎肝硬化血管重塑研究思路  

Research Ideas of Traditional Chinese Medicine in Improving Revascularization of Hepatitis B Cirrhosis

作　　者：赵志敏[1,2] 李正鑫 朱亭亭 刘成海 ZHAO Zhimin;LI Zhengxin;ZHU Tingting;LIU Chenghai(Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai,201203;Shanghai Key Laboratory of Traditional Chinese Medicine;Shanghai Innovation Center of TCM Health Service)

机构地区：[1]上海中医药大学附属曙光医院,上海市浦东新区201203 [2]上海市中医临床重点实验室 [3]上海中医健康服务协同创新中心

出　　处：《中医杂志》2020年第15期1318-1321,共4页Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(81473404,81730109);国家科技重大专项(2014ZX10005001)。

摘　　要：乙型肝炎肝硬化发展过程中肝脏血管稳态失衡、血管重塑是影响疾病进展和逆转的重要病理改变,且血管重塑分子机制复杂。乙型肝炎肝硬化是中医药治疗优势病种,中药具有多层次、多靶点综合治疗的特点适合血管重塑的整体调节。因此,需利用多学科交叉及系统生物学的方法和策略来探讨中医药改善乙型肝炎肝硬化血管重塑的可能作用机制,从而发现药物治疗的关键靶点。In the development of hepatitis B cirrhosis, unbalanced liver blood vessel and vascular remodeling are important pathological changes that affect disease progression and reversal, and the molecular mechanism of hepatitis B cirrhosis vascular remodeling is complex. Traditional Chinese Medicine(TCM) has dominant position in treatment of hepatitis B cirrhosis, TCM has the characteristics of multi-level and multi-target comprehensive treatment, and is suitable for the overall regulation of vascular remodeling. Therefore, it is necessary to use multidisciplinary cross-cutting and systems biology methods and strategies to explore the possible mechanism of action of TCM to improve the vascular remodeling of hepatitis B cirrhosis, so as to discover the key targets of the therapy.

关 键 词：乙型肝炎 肝硬化 血管重塑 中医药疗法 血管稳态 

分 类 号：R259[医药卫生—中西医结合]