盆底器官脱垂遗传易感基因研究进展  

Genetic susceptibility genes for pelvic organ prolapse

作　　者：陶成斌 王剑[2] 毛宝宏[2] 刘希云 魏颖 刘青[3] TAO Chengbin;WANG Jian;MAO Baohong;LIU Xiyun;WEI Ying;LIU Qing(Clinical Medical College,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Scientific Research Center,Gansu Provincial Maternity and Child-care Hospital,Lanzhou,Gansu,730050,China;Department of Gynecology of Combined Traditional Chinese and Western Medicine,Gansu Provincial Maternity and Child-care Hospital,Lanzhou,Gansu,730050,China)

机构地区：[1]甘肃中医药大学临床医学院,甘肃兰州730101 [2]甘肃省妇幼保健院科研中心,甘肃兰州730050 [3]甘肃省妇幼保健院中西医结合妇科,甘肃兰州730050

出　　处：《甘肃中医药大学学报》2020年第4期95-98,共4页Journal of Gansu University of Chinese Medicine

基　　金：国家“十二五”科技支撑计划项目(020054);甘肃省自然科学基金项目(17YF1FA109,18JR3RA032)。

摘　　要：查阅文献,从细胞外基质的合成、降解、代谢相关基因,雌激素受体基因,肌肉组织代谢相关基因等方面对盆底器官脱垂遗传易感基因的相关研究进展进行归纳、总结,从而为研究与盆底器官脱垂患者遗传易感性有关的早期遗传学指标、开展与盆底器官脱垂相关的一级预防提供新的思路和方向。Based on literature review,this paper generalizes and summarizes the research progress of genetic susceptibility genes for pelvic organ prolapse(POP)from the aspects of extracellular matrix(ECM)synthesis,degradation,metabolism related genes,estrogen receptor genes,muscular tissue metabolism related genes etc.,so as to provide new thinking and direction for studying the early genetic indicators of POP in patients and carrying out primary prevention related to it.

关 键 词：盆底器官脱垂 易感基因 细胞外基质 雌激素受体基因 肌肉组织代谢相关基因 综述 

分 类 号：R711.2[医药卫生—妇产科学]