夫妻配偶双方生殖器人乳头瘤病毒感染情况分析  

The analysis of HPV infection of genitals among heterosexual couples

作　　者：王光演 谷杭芝[1] 林风 胡燕[1] WANG Guang-yan;GU Hang-zhi;LIN Feng;HU Yan(Department of Gynecology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第一医院妇科,浙江温州325000

出　　处：《中华全科医学》2020年第10期1691-1694,共4页Chinese Journal of General Practice

基　　金：浙江省自然科学基金(LY19H040003)。

摘　　要：目的探讨女性宫颈人乳头瘤病毒(HPV)感染者其男性配偶外生殖器H PV感染情况以及男女双方HPV亚型吻合情况。方法收集2017年11月-2019年4月在温州医科大学附属第一医院就诊的443对女性宫颈H PV阳性者及其男性配偶的临床资料,采集男性的外生殖器上皮细胞和女性的宫颈脱落细胞,检测其HPV感染情况,总共包含27种高危和低危亚型,并对结果进行分析。结果在443例男性中检测出H P V阳性216例,感染率为48.76%,检出率前3位H PV亚型为HPV53、52、16,均为高危亚型,其妻子H PV感染率前3位同样为:HPV53、16、52。男女双方在低危亚型的检出率不一致,男性前2名分别是HPV43、61,而女性是HPV81、6。将216对性伴侣双方H PV阳性的基因亚型配对,结果显示HPV完全吻合率为26.39%(57/216),部分吻合率为36.11%(78/216),总体吻合率为62.50%(135/216),以1种H PV吻合为主,其中高危亚型占多数。结论女性宫颈HPV感染者其男性配偶外生殖器HPV感染率偏高。配偶双方均感染HPV者其HPV亚型吻合度高,尤其在高危亚型上。建议常规对女性宫颈H PV阳性者的男性配偶进行H PV筛查和治疗,从而提高双方H PV的清除率。Objective To investigate Human papilloma virus(HPV)prevalence and genotype distribution of males whose female partners with cervical HPV infection and the HPV type-specific concordance between heterosexual couples.Methods A total of 443 heterosexual couples,among whom female partners had cervical HPV infection,were enrolled in our hospital from November 2017 to April 2019.The swab samples from males"external genital epithelial cells and females"cervical exfoliated cells were collected and 27 HPV subtypes both high-risk and low-risk types were detected.The results were analyzed.Results Among 443 males,HPV infection was positive in 216 with an infective rate of 48.76%.The top three HPV subtypes in males were 53,52,16,while the top three HPV subtypes among their wives also were 53,16,52.The prevalence of low-risk HPV subtypes between couples was different,the top two in men were HPV43,61,while HPV81,6 in women.Among 216 both HPV positive sexual partners the complete and partial concordance rate of HPV were 26.39%(57/216)and 36.11%(78/216),the total concordance rate was 62.50%(135/216),most of concordant subtype was single type,especially in high-risk HPV.Conclusion The HPV infective rate of malesxexternal genital was slightly high among whose female partners had cervical HPV infection.The concordance rate of HPV subtypes in which both couples had HPV infection was high,especially in high-risk subtypes.We recommend to detect HPV among males whose female partners had cervical HPV infection and to cure,so that to improve the HPV clearance rate.

关 键 词：人乳头瘤病毒 配偶 感染 吻合 

分 类 号：R446[医药卫生—诊断学] R737.33[医药卫生—临床医学]