冠心方加减联合瑞舒伐他汀治疗冠心病心肌梗死的疗效及对心脏功能、炎症反应的影响  

Curative Effect of Using Modified Guanxin Prescription Combined with Rosuvastatin in the Treatment of Coronary Heart Disease and Its Influences on Cardiac Function and Inflammatory Response

作　　者：李红[1] LI Hong(Department of Geriatrics,the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang Liaoning 110000,China)

机构地区：[1]辽宁中医药大学附属医院老年病科,辽宁沈阳110000

出　　处：《四川中医》2020年第7期97-100,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：辽宁省科学技术计划项目(编号:20142055)。

摘　　要：目的:观察冠心方加减联合瑞舒伐他汀治疗冠心病(CHD)心肌梗死(MI)的效果及对心脏功能、炎症反应的影响。方法:收集我院2018年1月~2019年1月收治的178例CHD合并MI患者作为研究对象,依据患者意愿分为观察组和对照组,对照组患者接受瑞舒伐他钙片治疗,观察组在对照组基础上加服冠心方加减治疗,比较两组临床总有效率、中医证候积分、心脏功能、炎症指标。结果:观察组总有效率明显高于对照组(P<0.05);观察组治疗后胸痛、胸闷、心悸、腰膝酸软评分显著低于对照组(P<0.05);观察组治疗后左室射血分数(LVEF)显著高于对照组,左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)显著低于对照组(P<0.05);观察组患者治疗后超敏C反应蛋白(hs-CRP)、白介素18(IL-18)、白介素6(IL-6)以及肿瘤坏死因子-α(TNF-α)水平均明显低于对照组(P<0.05)。结论:冠心方加减联合瑞舒伐他汀治疗CHD合并MI患者,能够取得良好的临床效果,且对改善心脏功能、降低炎症反应具有积极意义。Objective:To explore the curative effect of Modified Guanxin Prescription combined with rosuvastatin on coronary heart disease(CHD)and myocardial infarction(MI)and their influences on cardiac function and inflammatory response.Methods:A total of 178 patients with CHD and MI who were admitted to the hospital from January 2018 to January 2019 were enrolled.They were divided into observation group and controlled group according to their wishes.The controlled group was given Rosuvastatin Calcium Tablets.On this basis,the observation group was additionally given Modified Guanxin Prescription.The total clinical response rate,TCM syndromes scores,cardiac function and inflammation indexes were compared between the two groups.Results:The total response rate of the observation group was significantly higher than that of the controlled group(P<0.05).After treatment,scores of chest pain,chest tightness,palpitation,soreness and weakness of waist and knees in the observation group were significantly lower than those in the controlled group(P<0.05).After treatment,left ventricular ejection fraction(LVEF)in the observation group was significantly higher than that in the controlled group,while left ventricular end-diastolic volume(LVEDV)and left ventricular end-systolic volume(LVESV)were significantly lower than those in the controlled group(P<0.05).After treatment,levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-18(IL-18),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower than those in controlled group(P<0.05).Conclusion:The clinical curative effect of Modified Guanxin Prescription combined with rosuvastatin is good on patients with CHD and MI,which is of positive significance for improving cardiac function and reducing inflammation response.

关 键 词：冠心方 瑞舒伐他汀 冠心病 心肌梗死 

分 类 号：R541.4[医药卫生—心血管疾病]