温针灸联合柴胡疏肝散加味对三叉神经痛患者血清β-内啡肽、P物质及氧化应激反应的影响  

Effect of Warm Acupuncture Combined with Modified Chaihu Shugan Powder on Serumβ-endorphin,Substance P and Oxidative Stress for Patients with Trigeminal Neuralgia

作　　者：魏会玲 宋世庆[2] 王建军 WEI Huiling;SONG Shiqing;WANG Jianjun(Department of Rehabilitation,Lingcheng District Hospital of Traditional Chinese Medicine of Dezhou City,Dezhou Shandong 253500,China;Department of Acupuncture and Moxibustion,Yuhuangding Hospital of Yantai,Yantai Shandong 264000,China;Department of Traditional Chinese Medicine,Lijin County Central Hospitaln,Lijin Shandong 257400,China)

机构地区：[1]德州市陵城区中医院康复科,山东德州253500 [2]烟台毓璜顶医院针灸科,山东烟台264000 [3]利津县中心医院中医科,山东利津257400

出　　处：《四川中医》2020年第7期183-186,共4页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:观察温针灸联合柴胡疏肝散加味对三叉神经痛患者血清β-内啡肽、P物质及氧化应激反应的影响。方法:选择2016年2月至2019年1月在我院接受治疗的原发性三叉神经痛患者78例进行研究,采用随机数字表法将患者分为2组,每组各39例。对照组给予温针灸治疗,观察组在此基础上加以柴胡疏肝散加味治疗。对比两组患者临床疗效、疼痛情况、血清β-内啡肽、P物质、氧化应激反应及不良反应。结果:观察组总有效率为92.31%,明显高于对照组的74.36%(P<0.05)。治疗后两组患者VAS评分及P物质水平均明显下降,但观察组下降更明显(P<0.05)。治疗后两组患者β-内啡肽均明显升高,但观察组升高更明显(P<0.05)。治疗后两组患者血清丙二醛水平均明显下降,但观察组下降幅度更大(P<0.05)。治疗后两组患者超氧化物歧化酶及谷胱甘肽水平均明显升高,但观察组升高更明显(P<0.05)。观察组出现3例(7.69%)不良反应,对照组出现5例(12.82%)不良反应,两组不良反应发生率对比差异无统计学意义(P>0.05)。结论:温针灸联合柴胡疏肝散加味治疗三叉神经痛较单独使用温针灸可明显提高临床疗效且不增加不良反应发生率,其作用机制可能与降低P物质,升高β-内啡肽水平,缓解氧化应激反应有关。Objective:To investigate the effect of warm needling combined with Modified Chaihu Shugan Powder on serum beta-endorphin,substance P and oxidative stress for patients with trigeminal neuralgia.Methods:A total of 78 patients with primary trigeminal neuralgia who were treated in our hospital from February 2016 to January 2019 were enrolled.Patients were divided into 2 groups using a random number table method,with 39 cases in each group.The controlled group was treated with warm acupuncture and moxibustion.The observation group was treated with Modified Chaihu Shugan Powder on this basis.The clinical efficacy,pain,serum β-endorphin,substance P,oxidative stress and adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 92.31%,which was significantly higher than that of the controlled group(74.36%)(P<0.05).After treatment,the VAS score and substance P level of the two groups were significantly decreased,but the decrease was more obvious in the observation group(P<0.05).After treatment,β-endorphin was significantly increased in both groups,but the increase in the observation group was more significant(P<0.05).Serum malondialdehyde levels decreased significantly in the two groups after treatment,but the decrease in the observation group was greater(P<0.05).After treatment,the levels of superoxide dismutase and glutathione were significantly increased in the two groups,but the increase in the observation group was more significant(P<0.05).There were 3 cases(7.69%)of adverse reactions in the controlled group and 5 cases(12.82%)in the controlled group.There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Warm acupuncture combined with Modified Chaihu Shugan Powder can significantly improve the clinical efficacy of trigeminal neuralgia without increasing the incidence of adverse reactions.Its mechanism may be related to reducing substance P,increasing the level of beta-endorphin and alleviating oxid

关 键 词：温针灸 柴胡疏肝散加味 三叉神经痛 作用机制 

分 类 号：R246.6[医药卫生—针灸推拿学] R745.11[医药卫生—中医临床基础]