锆基路易斯酸催化γ-戊内酯与胺的反应研究  

Study on Reaction ofγ-Valerolactone and Amine Catalyzed by Zirconium-Based Lewis Acids

作　　者：孔庆山 李兴龙[2] 许华建 傅尧[2] Kong Qingshan;Li Xinglong;Xu Huajian;Fu Yao(School of Food and Biological Engineering,University of Science and Technology of China,Hefei 230601;Hefei National Laboratory for Physical Sciences at the Microscale,Collaborative Innovation Center of Chemistry for Energy Materials,Chinese Academy of Sciences Key Laboratory of Urban Pollutant Conversion,Anhui Province Key Laboratory of Biomass Clean Energy,Department of Chemistry,University of Science and Technology of China,Hefei 230026)

机构地区：[1]合肥工业大学食品与生物工程学院,合肥230601 [2]中国科学技术大学化学系,合肥微尺度物质科学国家实验室,能源材料化学协同创新中心,中国科学院城市污染物转化重点实验室,安徽省生物质洁净能源重点实验室,合肥230026

出　　处：《有机化学》2020年第7期2062-2070,共9页Chinese Journal of Organic Chemistry

基　　金：国家重点研发项目(No.2018YFB1501604);国家自然科学基金(No.21472033);安徽省重点科研开发项目(No.201904a07020069);中央高校基础研究基金资助项目.

摘　　要：γ-戊内酯(GVL)是重要的生物质平台分子,将其转化为高附加值的化学品和燃料,具有重要的应用前景.介绍了一种在温和条件下通过还原胺化/环化反应,分别使用锆基路易斯酸催化剂Zr-P-O和ZrOCl2·8H2O,催化GVL与胺类化合物合成羟基酰胺类化合物和吡咯烷酮类化合物.特别值得一提的是,在无溶剂的情况下,均可以得到中等偏上的产物收率.该方法为GVL的应用研究进一步奠定了基础.γ-Valerolactone(GVL)is an important biomass platform molecule,it can be converted into high value-added chemicals and fuel,which has important application prospects.This article describes a method for the synthesis of hydroxyamides and pyrrolidones from GVL and amine compounds by reductive amination/cyclization reactions under mild conditions using zirconium-based Lewis acid catalysts Zr-P-O and ZrOCl2·8H2O,respectively.In particular,a moderately high product yield can be obtained with the absence of a solvent.This method further lays the foundation for the application research of GVL.

关 键 词：γ-戊内酯 羟基酰胺 吡咯烷酮 路易斯酸催化 锆基催化剂 

分 类 号：O621.251[理学—有机化学]