镍催化分子氧氧化脱氢偶联反应制备N-芳基四氢异喹啉化合物  

Nickel(Ⅱ)-Catalyzed Aerobic Cross-Dehydrogenative Coupling for the Synthesis of N-Aryl Tetrahydroisoquinolines

作　　者：王慧 王安玮 夏珍珍 周维友[1] 孙中华 钱俊峰[1] 何明阳[1] Wang Hui;Wang Anwei;Xia Zhenzhen;Zhou Weiyou;Sun Zhonghua;Qian Junfeng;He Mingyang(Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology,School of Petrochemical Engineering,Changzhou University,Changzhou,Jiangsu 213164)

机构地区：[1]常州大学石油化工学院江苏省绿色催化材料与技术重点实验室,江苏常州213164

出　　处：《有机化学》2020年第7期2099-2107,共9页Chinese Journal of Organic Chemistry

基　　金：江苏省绿色催化材料与技术重点实验室基金(No.BM2012110);江苏省研究生科研与实践创新计划(No.KYCX19_1746);江苏省自然科学基金(No.BK20181461)资助项目.

摘　　要：以NiCl2为催化剂催化N-四氢异喹啉的分子氧氧化脱氢偶联反应,以较高产率制备了一系列N-芳基四氢异喹啉化合物.该方法对不同的N-四氢异喹啉衍生物和亲核试剂均具有较好的适用性,反应均能以较高的产率获得相应的目标产物.与已有方法相比,本方法采用分子氧为氧化剂,具有反应条件温和、底物适用范围广、操作简便等优点,为四氢异喹啉衍生物的制备提供了一种有效途径.An nickel-catalyzed aerobic cross-dehydrogenative coupling of N-aryl tetrahydroisoquinolines is presented.The catalytic system could tolerate various N-aryl tetrahydroquinoline derivatives and nucleophiles,and the target products could be obtained in good to excellent yields.Compared with reported methods,the protocol uses molecular oxygen as a sustainable oxidant,and provides an effective approach to the synthesis of tetrahydroisoquinoline derivatives under mild and practical conditions.

关 键 词：脱氢偶联 C—H活化 镍 分子氧 N-芳基四氢异喹啉 

分 类 号：O626.323[理学—有机化学]