鸟巢烷二萜关键中间体的合成  

Synthesis of Key Intermediate of Cyathane Diterpenes

作　　者：李若馨 韩锐 高锦明 Li Ruoxin;Han Rui;Gao Jinming(Shanxi Key Laboratory of Natural Products Chemistry and Biology,College of Chemistry&Pharmacy,Northwest A&F University,Yangling,Shaanxi 712100)

机构地区：[1]西北农林科技大学化学与药学院陕西省天然产物化学生物学重点实验室,陕西杨陵712100

出　　处：《有机化学》2020年第7期2148-2152,共5页Chinese Journal of Organic Chemistry

摘　　要：开发了一种鸟巢烷型二萜类天然产物关键二环[5/6]中间体的合成策略,该策略涉及亲核取代反应、自由基关环反应、Johnson-Claisen重排和格氏加成等一系列反应,并对反应条件进行优化.该路线具有高效、简洁的优点,在此类天然产物的全合成中有较大的应用潜力.A synthetic plan of bicyclo[5/6]key intermediate of cyathane is reported.All the involved reactions,such as nucleophilic substitution reaction,radical ring-closing reaction,Johnson-Claisen rearrangement and Grignard addition,were optimized for higher yields.The procedure provides a simple and efficient method for the synthesis of bicyclo-key intermediate of cyathane.It is expected to have wide applications in the synthesis of cyathane.

关 键 词：鸟巢烷型二萜 天然产物 亲核取代 CLAISEN重排 

分 类 号：O629.61[理学—有机化学]