益肺活血汤结合西医常规疗法对慢性阻塞性肺疾病氧化/抗氧化失衡的影响  

Effect of Yifei-Huoxue Decoction combined with conventional western medicine on patients of oxidant-antioxidant imbalancewith chronic obstructive pulmonary disease

作　　者：翟云青[1] 张学平[1] 马志英[1] Zhai Yunqing;Zhang Xueping;Ma Zhiying(Department of Respiration,Binzhou Center Hospital,Binzhou 251700,China)

机构地区：[1]山东省滨州市中心医院呼吸科,251700

出　　处：《国际中医中药杂志》2020年第6期543-546,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的探讨益肺活血汤结合西医常规疗法对COPD患者氧化/抗氧化失衡的影响。方法将符合入选标准的2016年1月-2018年12月本院患者102例,按随机数表法分为2组,每组51例。对照组给予西医常规疗法治疗,研究组在对照组基础上加服益肺活血汤。2组均连续治疗14 d。分别于治疗前后进行中医症状评分,采用肺功能仪测定FEV1占预计值百分比,计算FVC;采用血气分析仪测定动脉血PaO2、PaCO2;采用ELISA法检测血清MDA、SOD、GSH-Px水平,评价临床疗效。结果研究组总有效率为98.0%(50/51)、对照组为80.4%(41/51),2组比较差异有统计学意义(χ^2=8.254,P=0.004)。研究组治疗后咳嗽、咳痰、气喘、心慌、胸闷、乏力评分均低于对照组(t值分别为3.716、6.524、5.032、2.516、4.804、2.882,P<0.05或P<0.01)。治疗后,研究组FEV1占预计值百分比[(68.05±6.11)%比(59.02±5.45)%,t=7.876]、FEV1/FVC[(60.10±5.83)比(54.05±5.07),t=5.592]、PaO2[(67.79±3.82)mmHg比(60.63±3.55)mmHg,t=9.805]均高于对照组(P<0.01),PaCO2[(56.08±2.25)mmHg比(61.14±2.13)mmHg,t=11.663]低于对照组(P<0.01);血清MDA[(3.21±0.63)μmol/L比(4.95±0.87)μmol/L,t=11.568]水平低于对照组(P<0.01),SOD[(73.35±8.97)μU/ml比(61.68±7.82)μU/ml,t=7.003]、GSH-Px[(170.35±17.72)U/ml比(149.14±15.04)U/ml,t=6.517]水平高于对照组(P<0.01)。结论益肺活血汤结合西医常规疗法可明显改善COPD患者的肺功能,纠正氧化/抗氧化失衡状态,提高临床疗效。Objective To explore the effect of Yifei-Huoxue Decoction combined with conventional western medicine on patients with oxidant-antioxidant imbalance with COPD.Methods A total of 102 patients who met the inclusion criteria from January 2016 to December 2018 were divided into two groups,according to the random table method,51 cases in each group.The control group was treated with conventional western medicine,while the research group was treated with Yifei-Huoxue Decoction based on control group.Both the two groups were treated for 14 days.The traditional Chinese medicine symptom scores of the two groups were compared before and after the treatment.The forced expiratory volume in one second/predicted value ratio(FEV1%pred)was measured by pulmonary function instrument,FEV1/forced vital capacity(FVC)was calculated.Partial pressure of oxygen(PaO2)and partial pressure of carbon dioxide(PaCO2)were measured by blood gas analyzer.The levels of MDA,SOD and Glutathioneperoxidase(GSH-Px)were detected by ELISA,and the clinical effect was evaluated.Results The total effective rate of research group was 98.0%(50/51),the control group was 80.4%(41/51),and the difference between the two groups was statistically significant(χ2=8.254,P=0.004).After the treatment,the scores of cough,expectoration,asthma,panic,chest distress and fatigue in the research group were significantly lower than those of the control group(t values were 3.716,6.524,5.032,2.516,4.804 and 2.882,respectively,all Ps<0.05).After the treatment,the FEV1%pred(68.05%±6.11%vs.59.02%±5.45%,t=7.876),FEV1/FVC(60.10±5.83 vs.54.05±5.07,t=5.592),PaO2(67.79±3.82 mmHg vs.60.63±3.55 mmHg,t=9.805)in the research group were significantly higher than those of the control group(P<0.05),the PaCO2(56.08±2.25 mmHg vs.61.14±2.13 mmHg,t=11.663)was significantly lower than that of the control group(P<0.01),the levels of serum MDA(3.21±0.63 mmol/L vs.4.95±0.87 mmol/L,t=11.568)was significantly lower than that of the control group(P<0.01),the levels of SOD(73.35±8.97μU/ml vs.6

关 键 词：肺疾病 慢性阻塞性 益肺活血汤 氧化/抗氧化失衡 中西医结合疗法 

分 类 号：R563.9[医药卫生—呼吸系统]