大黄䗪虫丸抗肿瘤作用机制及临床应用研究进展  

Research progress of anti-tumor mechanism and clinical application of Dahuang-Zhechong Pill

作　　者：郑文利[1] 郑祎[2] 李慧杰[3] 齐元富[3] Zheng Wenli;Zheng Yi;Li Huijie;Qi Yuanfu(Master Degree Student of Grade 2012,Shandong University of Traditional Chinese Medicine,Jinan 250014,China;Department of Oncology,Affiliated Hospital of Weifang Medical College,Weifang 261031,China;Department of Oncology,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学2012级硕士研究生,济南250014 [2]山东省潍坊医学院附属医院肿瘤科,261031 [3]山东中医药大学附属医院肿瘤科,济南250014

出　　处：《国际中医中药杂志》2020年第6期609-611,共3页International Journal of Traditional Chinese Medicine

基　　金：山东省中医药科技发展计划项目(2017-220)。

摘　　要：综述《金匮要略》大黄䗪虫丸作用机制及临床应用研究相关文献,发现大黄䗪虫丸主要通过抑制细胞增殖、诱导细胞凋亡、调节免疫功能、抑制肿瘤血管生成、影响肿瘤细胞转移、逆转细胞耐药等途径实现抗肿瘤作用,多用于治疗肝癌、胃癌、食管癌、肺癌等恶性肿瘤;应进一步明确其抗肿瘤机制、优势剂型、优势瘤种,并对其治疗剂量及不良反应发生剂量进一步规范。This paper reviewed the mechanism and clinical application of Dahuang-Zhezhong Pill in Jin Gui Yao Lue.It was found that the anti-tumor effect of Dahuang-Zhezhong Pill was mainly achieved by inhibiting cell proliferation,inducing cell apoptosis,regulating immune function,inhibiting tumor angiogenesis,affecting tumor cell metastasis,and reversing cell resistance.It was used in the treatment of liver cancer,gastric cancer,esophageal cancer,lung cancer and other malignant tumors.Therefore,we should clarify the anti-tumor mechanism,the dominant dosage,the dominant tumor species of Dahuang-Zhezhong Pill,and standardize the dosage of treatment and adverse reactions.

关 键 词：大黄䗪虫丸 恶性肿瘤 抗肿瘤剂(中药) 作用机制 临床应用 综述 

分 类 号：R285.5[医药卫生—中药学] R273[医药卫生—中医学]