重症中毒脑水肿肿瘤坏死因子α对水通道蛋白4表达相关性的探讨  

The discussion of the correlation between tumor necrosis factor-alpha and aquaporin 4 expression in critical poisoning brain edema

作　　者：程岳雷 刘健 李盟 Cheng Yuelei;Liu Jian;Li Meng(Department of Emergency Medicine of the Second Affiliated Hospital of Shandong First Medical University,Shandong Provincial Key Laboratory of Clinical Poisoning Research,Taian 271000,China;Intensive Care Unit of Beijing Wangfu Integrated Traditional Chinese and Western Medicine Hospital,Beijing 100049,China)

机构地区：[1]山东第一医科大学第二附属医院急诊医学科,山东省临床中毒研究重点实验室,泰安271000 [2]北京王府中西医结合医院重症监护室,100049

出　　处：《中华劳动卫生职业病杂志》2020年第7期553-555,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：重症中毒是一种危急症,中毒后脑水肿是中毒急性期脑损伤后导致患者病情加重和影响患者预后的重要因素之一。水通道蛋白4(aquaporin 4,AQP-4)是水通道蛋白家族的重要成员,在中枢神经系统中有着丰富的表达,对脑水肿的形成起重要作用。脑损伤可以引起炎性递质的分泌,造成或加重继发性脑水肿,其中肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)被证实与脑水肿关系最为密切,可通过调控AQP-4参与脑水肿的形成和发展。Critical poisoning is a critical illness.Cerebral edema after poisoning is one of the important factors that cause the patient's condition to worsen and affect the prognosis of patients after acute brain injury.Aquaporin 4(AQP-4)is an important member of the aquaporin family and is abundantly expressed in the central nervous system,playing a pivotal role in the formation of cerebral edema.Brain injury can cause the secretion of inflammatory transmitters,causing or aggravating cerebral edema.Tumor necrosis factor-alpha(TNF-α)has been confirmed to be most closely related to cerebral edema,and can participate in the formation and development of brain edema by regulating AQP-4.

关 键 词：脑水肿 重症中毒 肿瘤坏死因子Α 水通道蛋白4 

分 类 号：R595[医药卫生—内科学]