Protective Effects of Salvianolate on Myocardial Injury or MyocardiaMnfarction after Elective Percutaneous Coronary Intervention in NSTE-ACS Patients:A Randomized Placebo-Controlled Trial  

作　　者：OU Yang SUN Sheng-jia SHI Hai-ming LUO Jian-feng LUO Xin-ping SHEN Yun-zhi CHEN Yu-fei FAN Wei-hu LIU Hong-ying SHEN Wei 

机构地区：[1]Department of Cardiovascular Disease,Huashan Hospital,Fudan University,Shanghai(200040),China [2]Department of Biostatistics,School of Public Health,Fudan University,Shanghai(200032),China [3]Medical Department,Shanghai Green Valley Pharmaceutical Co.,Ltd.,Shanghai(201203),China

出　　处：《Chinese Journal of Integrative Medicine》2020年第9期656-662,共7页中国结合医学杂志（英文版）

基　　金：the National Natural Science Foundation of China(No.81673701 and No.81573710)。

摘　　要：Objective:To evaluate the protective effects of salvianolate on percutaneous coronary intervention(PCI)related myocardial injury or myocardial infarction after elective PCI in non-ST-segment elevation acute coronary syndrome(NSTE-ACS)patients.Methods:A total of 149 patients with NSTE-ACS who underwent elective PCI were enrolled.The patients were randomly allocated in a 1:1 ratio to the salvianolate group(74 cases)or the control group(75 cases).After exclusion criteria of coronary angiography,60 patients with PCI therapy remained in the salvianolate group and 68 in the control group.The incidence and the severity of PCI related myocardial injury or myocardial infarction,in addition to major adverse cardiac events(MACEs)during 1 year follow-up after PCI were studied between the two groups.Multivariate logistic regression analysis was used to determine the independent factors for PCI related myocardial injury or myocardial infarction after elective PCI.Results:Compared with the control group,salvianolate treatment reduced the incidence of PCI related severe myocardial injury or myocardial infarction(11.7%vs.26.5%,P=0.035).The rate of MACEs or all-cause death within 1 month or 1 year after the procedure was not significantly different between the two groups.Conclusions:Periprocedural treatment with salvianolate reduces the incidence of PCI related severe myocardial injury or myocardial infarction,although it does not influence clinical prognosis.

关 键 词：myocardial infarction acute coronary syndrome percutaneous coronary intervention SALVIANOLATE 

分 类 号：R542.22[医药卫生—心血管疾病]