外周血细胞参数对川崎病临床预测作用的研究进展  

Research progress of peripheral blood cell parameters in clinical prediction of Kawasaki disease

作　　者：吴业媚 徐明国 Wu Yemei;Xu Mingguo(Zhuhai Campus of Zunyi Medical University,Zhuhai 519041,Guangdong Province,China)

机构地区：[1]遵义医科大学珠海校区,广东珠海519041

出　　处：《中华实用儿科临床杂志》2020年第13期1027-1030,共4页Chinese Journal of Applied Clinical Pediatrics

摘　　要：外周血细胞参数,如中性粒细胞/淋巴细胞、血小板计数/淋巴细胞和平均血小板体积/淋巴细胞是系统性炎症标志物,对心血管疾病、肿瘤、全身炎性反应等疾病的发生、疗效和预后的判断有预测意义。目前已有研究表明,中性粒细胞百分比、血清清蛋白、C反应蛋白、红细胞比容、血小板计数、血清钠、总胆红素、氨基末端脑钠肽前体(NT-proBNP)等是预测川崎病患儿冠状动脉病变或免疫球蛋白抵抗的常见独立危险因素。近期研究表明,外周血细胞参数对川崎病患儿冠状动脉病变和免疫球蛋白抵抗有预测价值。因血常规廉价、操作简单易行而具有广泛的临床应用前景。现就外周血细胞参数预测川崎病患儿冠状动脉病变及免疫球蛋白抵抗的研究进展进行综述。Peripheral blood cell parameters such as neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and the mean platelet volume-to-lymphocyte ratio are markers of systemic inflammation,which can predict the occurrence,efficacy and prognosis of cardiovascular diseases,tumors,systemic inflammatory reactions and other di-seases.Current studies show that neutrophil percentage,serum albumin,C-reactive protein,erythrocyte hematocrit,platelet count,serum sodium,total bilirubin,and N-terminal pro B type natriuretic peptide(NT-proBNP)are co-mmon independent risk factors of coronary artery lesions or immunoglobulin resistance in children with Kawasaki disease.New research suggests that peripheral blood cell parameters have predictive value for coronary artery lesions and immunoglobulin in children with Kawasaki disease.Peripheral blood cell parameters have wide applications due to the cheap and simple routine blood test.In this paper,the research progress in predicting coronary artery disease and immunoglo-bulin resistance in children with Kawasaki disease by peripheral blood cell parameters was reviewed.

关 键 词：川崎病 中性粒细胞/淋巴细胞 血小板计数/淋巴细胞 平均血小板体积/淋巴细胞 冠状动脉病变 静脉用免疫球蛋白抵抗 

分 类 号：R725.4[医药卫生—儿科]