夏枯草膏联合常规疗法治疗颈部淋巴结核的疗效及对免疫功能和炎症因子水平的影响  

Effect of Prunella Vulgaris Ointment Combined with Routine Therapy on Treatment of Cervical Lymph Node Nucleus and Its Effect on Immune Function and level of Inflammatory Factor

作　　者：杨国强[1] 张靳 张绿浪 杨佳[4] 李同心[5] YANG Guo-qiang;ZHANG Jin;ZHANG Lv-lang;YANG Jia;LI Tong-xin(General Orthopedic Department,Chongqing Public Health Medical Center,Chongqing,400036;Rehabilitation Center,Chongqing Children's Welfare Institute,Chongqing,400055;Infectious Disease Department,Chongqing Public Health Medical Center,Chongqing,400036;Radiological Department,Chongqing Public Health Medical Center,Chongqing,400036;Clinical Laboratory,Chongqing Public Health Medical Center,Chongqing,400036)

机构地区：[1]重庆市公共卫生医疗救治中心普外骨科,重庆400036 [2]重庆市儿童福利院康复中心,重庆400055 [3]重庆市公共卫生医疗救治中心感染一科,重庆400036 [4]重庆市公共卫生医疗救治中心放射科,重庆400036 [5]重庆市公共卫生医疗救治中心检验科,重庆400036

出　　处：《中国中西医结合杂志》2020年第8期914-918,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：2018年重庆市科卫联合中医药科技项目(No.ZY201802098)。

摘　　要：目的观察夏枯草膏治疗颈部淋巴结核的疗效及对T淋巴细胞亚群和炎症因子水平的影响。方法将纳入本研究的127例颈部淋巴结核患者随机分为夏枯草组(63例)及对照组(64例)。对照组患者给予常规抗结核治疗方案2HRZE/4HR;夏枯草组患者在对照组的基础上服用夏枯草膏。两组患者均治疗6个月。采集患者治疗前后的静脉血,使用流式细胞仪检测CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平,采用ELISA法检测IL-10、TNF-α水平。同时,观察并分析两组临床疗效、症状缓解情况与治疗期间的不良反应发生情况。结果治疗后随访1年,夏枯草组脱落3例,对照组4例。治疗后夏枯草组总有效率(90.00%,54/60)优于对照组(75.00%,45/60,χ^2=4.675,P<0.05)。与本组治疗前比较,两组患者血清CD3^+、CD4^+、CD4^+/CD8^+、IL-10水平升高,TNF-α水平降低(P<0.05);与对照组比较,夏枯草组颈部淋巴结核患者颈部疼痛、发热、乏力症状缓解率、CD3^+、CD4^+、CD4^+/CD8^+、IL-10水平升高(P<0.05),转手术率及TNF-α水平降低(P<0.05,P<0.01)。两组患者血清CD8^+变化差异无统计学意义(P>0.05)。夏枯草组不良反应发生率(31.67%,19/60)与对照组(38.33%,23/60)比较,差异无统计学意义(χ^2=0.586,P>0.05)。结论夏枯草膏联合常规疗法治疗颈部淋巴结核可明显升高患者血清CD3^+、CD4^+、CD4^+/CD8^+、IL-10水平,降低TNF-α水平与转手术率,提高临床症状缓解率及临床治疗有效率,且不增加不良反应。Objective To observe the effect of Prunella vulgaris ointment combined with routine therapy on the immune function and the level of inflammatory factors in patients with cervical lymphadenitis.Methods Totally 127 cases of cervical tuberculosis were randomly assigned to Prunella vulgaris group(63 cases)and control group(64 cases).The patients in the control group were given the routine antituberculosis treatment scheme 2 HRZE/4 HR.The patients in Prunella vulgaris group took Prunella vulgaris ointment on the basis of control group.Both groups were treated for 6 months.Venous blood was collected before and after treatment.The levels of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+were measured by flow cytometry.The levels of IL-10 and TNF-αwere detected by ELISA.Meanwhile,the clinical efficacy and adverse reactions were observed.Results The patients were followed up for 1 year,control 3 cases in the Prunella vulgaris group and 4 cases in the control group were dropped out.After treatment,the total effective rate of Prunella vulgaris group was 90.00%(54/60),which was better than that of control group(75.00%,45/60,χ2=4.675,P<0.05).Compared with before treatment,the level of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+,IL-10 increased,the level of TNF-αdecreased after treatment in two groups(P<0.05).Compared with the control group,the relief rate of neck pain,fever and fatigue symptoms,the level of CD3^+,CD4^+,CD8^+,CD4^+/CD8^+,and IL-10 in the Prunella vulgaris group increased(P<0.05),the conversion rate and TNF-αlevel decreased(P<0.05,P<0.01).There was no significant difference in serum CD8^+between the two groups(P>0.05).There was no significant difference in incidence of adverse reactions of Prunella vulgaris group(31.67%,19/60)and control group(38.33%,23/60,χ2=0.586,P>0.05).Conclusion The combination of Prunella vulgaris Ointment and routine therapy in the treatment of cervical lymphadenitis can significantly improve the clinical symptom remission rate and clinical treatment efficiency,without increasing adverse reactions,improve the seru

关 键 词：夏枯草膏 颈部淋巴结核 免疫功能 炎症因子 

分 类 号：R522[医药卫生—内科学]