乌药产地鲜切加工工艺响应面优化研究  

Optimization of Response Surface of Fresh-cut Processing Technology of Linderae Radix in Producing Area

作　　者：王鑫昱 杜伟锋[2] 康显杰 顾超[2] 罗云云[2] 葛卫红[2] WANG Xinyu;DU Weifeng;KANG Xianjie;WU Yao;LUO Yunyun;GE Weihong(Affiliated Guangxing Hospital,Zhejiang Chinese Medical University,Hangzhou 310006,Zhejiang,China;Research Center of Traditional Chinese Medicine Processing Technology,Zhejiang Chinese Medical University,Hangzhou 311401,Zhejiang,China)

机构地区：[1]浙江中医药大学附属广兴医院,浙江杭州310006 [2]浙江中医药大学中药炮制技术研究中心,浙江杭州311401

出　　处：《中华中医药学刊》2020年第7期76-80,I0012,I0013,共7页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中药标准化项目(ZYBZH-H-ZY-45);国家中医药行业科研专项(201507002);浙江省公益性技术应用研究计划(2015C33152);浙江省重中之重一级学科——中药学学科科研开放基金(Yao2016018);浙江中医药大学重中之重一级学科开放基金(2016)。

摘　　要：目的通过响应面法优化乌药产地鲜切加工工艺,得到乌药产地鲜切加工的最佳工艺。方法以热风干燥温度,装载量,饮片切片厚度为考察因素,以浸出物得率,乌药醚内酯,乌药内酯、去甲异波尔定含量为考察指标,通过主成分分析法得到各指标的权重系数,计算综合评分,对3个考察因素进行单因素分析,得到初步优化范围,最后以响应面优化法进行优化,得到最后工艺优化参数。结果装载量的初步优化范围为6~10 kg/m^2,干燥温度的初步优化范围为55~75℃,切片厚度的初步优化范围为1~3 mm,经响应面优化法优化得到的加工工艺为装载量8 kg/m^2,干燥温度为65℃,切片厚度为2 mm。结论响应面法优化得到的乌药产地鲜切加工工艺稳定可行,可为乌药饮片的生产加工提供可靠的理论依据。Objective To optimize and obtain the best process of fresh-cut processing technology of Linderae Radix in origin area by response surface methodology.Methods Hot air drying temperature,loading amount and slice thickness were taken as investigation factors.The yield of extract,the content of chlorhexidine lactone,medicinal lactone and norbelopolide were taken as indicators.Weight coefficients of each indicator were obtained by principal component analysis.The comprehensive score was calculated,and the three factors were analyzed by single factor analysis to obtain the initial optimization range.Finally,the response surface optimization method was used to optimize the final optimization parameters.Results The initial optimization range of loading was 6~10 kg/m^2,the drying temperature range was 55~75℃and the slice thickness range was 1~3 mm.The processing technology optimized by the response surface methodology was loading capacity of 8 kg/m^2,drying temperature of 65℃,and slice thickness of 2 mm.Conclusion The fresh-cut processing technology of Linderae Radix processed by the response surface methodology was stable and feasible,which can provide a reliable theoretical basis for the production and processing of Linderae Radix.

关 键 词：乌药 产地鲜切加工 加工工艺 响应面优化 

分 类 号：R282.71[医药卫生—中药学]