基于维生素D探讨黄芪治疗2型糖尿病潜在靶点  

Discussion on Potential Target of Huangqi(Astragalus Membranaceus) in Treatment of Type 2 Diabetes Mellitus Based on Vitamin D

作　　者：吴雍真 高洁 李文 秦忠 李倩 张孟之 朱星 陈云志 柴艺汇 WU Yongzhen;GAO Jie;LI Wen;QIN Zhong;LI Qian;ZHANG Mengzhi;ZHU Xing;CHEN Yunzhi;CHAI Yihui(Guizhou University of Traditional Chinese Medicine,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州中医药大学,贵州贵阳550025

出　　处：《中华中医药学刊》2020年第7期110-112,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金(81660762,81460694,81874376);贵州省科技计划(黔科合基础[2017]1401);贵州省教育厅创新群体重大研究项目(黔教合KY字[2017]041);贵州省教育厅项目(黔教合KY[2016]013);贵州省一流学科建设项目(QYNYL[2017]005);贵州省中医药管理局项目(QZYY2017-012);贵阳中医学院研究生教育创新计划(YFYYJSCX2018-16)。

摘　　要：维生素D缺乏与2型糖尿病关系紧密,补充维生素D在一定程度上可改善病情。2型糖尿病属中医"消渴"范畴,主要病机为阴虚燥热,其中肾阴虚、肾火旺是阴虚燥热之源,故医家多从补肾固本展开治疗;研究发现,黄芪不仅能调节机体维生素D水平,还对2型糖尿病具有较好的防治作用。据此推测,黄芪治疗2型糖尿病可能通过调控维生素D发挥作用,维生素D可能是黄芪治疗2型糖尿病的潜在靶点。Type 2 diabetes mellitus is closely related to Vitamin D deficiency and vitamin D supplementation can effectively improve the condition.Type 2 diabetes mellitus belongs to the category of Xiaoke in traditional Chinese medicine.The main cause is Yin deficiency,dryness-heat and the source of Yin deficiency and dryness-heat is the cause of kidney Yin deficiency.Supplementing the kidney and consolidating the vital Qi are the main legislative rules for traditional Chinese medicine treatment.The study finds Huangqi(Astragalus Membranaceus)is closely related to vitamin D.Huangqi(Astragalus Membranaceus)can regulate vitamin D while preventing type 2 diabetes mellitus.According to the above,Huangqi(Astragalus Membranaceus)may play a role in regulating vitamin D and vitamin D may be a potential target for Huangqi(Astragalus Membranaceus)in the treatment of type 2 diabetes mellitus.

关 键 词：黄芪 维生素D 2型糖尿病 靶点 

分 类 号：R259.871[医药卫生—中西医结合]