超声造影定量参数对肺部良恶性病变鉴别诊断的价值研究  

Study on the differential diagnosis value of contrast-enhanced ultrasound quantitative parameters on benign and malignant lung lesions

作　　者：李敏[1] 李海文 陶运亮 王琼妹 LI Min;LI Haiwen;TAO Yunliang;WANG Qiongmei(Department of Ultrasound,Qionghai People′s Hospital,Qionghai,Hainan 571400,China;Department of Physical Examination,Qionghai People′s Hospital,Qionghai,Hainan 571400,China)

机构地区：[1]海南省琼海市人民医院超声科,571400 [2]海南省琼海市人民医院健康体检科,571400

出　　处：《重庆医学》2020年第16期2686-2689,2693,共5页Chongqing medicine

基　　金：海南省卫生厅项目(琼卫科教[2013]64号)。

摘　　要：目的探讨超声造影(CEUS)定量参数在肺部良恶性病变鉴别诊断的应用价值。方法选取2019年1-10月该院就诊的98例肺部病变患者(98个病灶)为研究对象,依据病理结果分为良性组41例(41个病灶)和恶性组57例(57个病灶),行二维超声、彩色多普勒超声和CEUS检查,比较两组二维超声表现(病灶位置、最大直径、形态、边缘、内部回声、空气支气管气相)、血流信号、CEUS时间-强度曲线(TIC)定量参数(上升时间、平均渡越时间、达峰时间、峰值强度、上升支斜率)、造影剂到达病灶和肺组织时间、病灶-肺组织时间差。结果两组形态、边缘、内部回声、空气支气管气相、血流信号比较,差异有统计学意义(P<0.05),但病灶部位、最大直径比较,差异无统计学意义(P>0.05)。良性组上升时间、达峰时间均低于恶性组(P<0.05),但两组平均渡越时间、峰值强度、上升支斜率比较,差异无统计学意义(P>0.05)。良性组造影剂到达病灶时间及病灶-肺组织时间差均低于恶性组(P<0.05),但两组造影剂到达肺组织时间比较,差异无统计学意义(P>0.05)。结论CEUS定量参数可用于鉴别肺部良恶性病变。Objective To explore the clinical application value of contrast-enhanced ultrasound(CEUS)quantitative parameters in the identification of benign and malignant lung lesions.Methods A total of 98 patients with lung lesions(98 lesions)treated in hospital from January 2019 to October 2019 were selected and divided into the benign group(n=41,41 lesions)and the malignant group(n=57,57 lesions)based on pathological results.Two-dimensional ultrasound,color doppler ultrasonography and CEUS examination were performed.The two-dimensional ultrasound performance(focal location,maximum diameter,morphology,margin,internal echo,air bronchogram sign),blood flow signal,CEUS time-intensity curve(TIC)quantitative parameters(ascending time,mean transit time,time to peak,peak intensity,base-to-peak ascending slope),time of contrast agent reaching lesions and lung tissues and time difference of lesions and lung tissues were compared between the two groups.Results There were statistically significant differences in terms of morphology,margin,internal echo,air bronchogram sign and blood flow signal between the benign group and the malignant group(P<0.05),while there were no statistical differences in the lesion site and maximum diameter between the two groups(P>0.05).The ascending time and time to peak in the benign group were lower than those in the malignant group(P<0.05).There were no significant differences in the mean transit time,peak intensity and base-to-peak ascending slope between the two groups(P>0.05).The time of contrast agent reaching lesions and time difference of lesions and lung tissues in the benign group were lower than those in the malignant group(P<0.05),and there was no statistically significant difference in the time of contrast agent reaching lung tissues between the two groups(P>0.05).Conclusion CEUS quantitative parameters can be used for the differential diagnosis of benign and malignant lesions.

关 键 词：超声检查 多普勒 静脉造影术 定量参数 肺 诊断 鉴别 

分 类 号：R445.1[医药卫生—影像医学与核医学] R734.2[医药卫生—诊断学]