CAD患者血清Hcy及SCr与冠状动脉病变程度的相关性研究  

Study on the correlation between serum Hcy,SCr and severity of coronary artery disease in patients with CAG

作　　者：黄煜淇 刘兴德[1] 文美[2] HUANG Yuqi;LIU Xingde;WEN Mei(Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Cardiology,the First People′s Hospital of Guiyang,Guiyang,Guizhou 550002,China)

机构地区：[1]贵州医科大学,贵阳550004 [2]贵州省贵阳市第一人民医院心内科,550002

出　　处：《重庆医学》2020年第16期2690-2693,共4页Chongqing medicine

基　　金：贵州省贵阳市人才创新创业资助项目[筑人才办合同字(2017)第11号]。

摘　　要：目的分析冠状动脉粥样硬化性心脏病(CAD)行冠状动脉造影(CAG)患者的血清同型半胱氨酸(Hcy)及血肌酐(SCr)水平与冠状动脉病变严重程度的相关性。方法收集2018年2月至2019年2月于该院心内科行冠状动脉造影(CAG)术的146例患者信息,根据造影结果分为CAD组及非CAD组,比较两组一般临床资料,计算冠状动脉病变Gensini积分,分析Hcy及SCr水平同Gensini积分相关性。结果CAD组Hcy及SCr水平均高于非CAD组(P<0.05)。二元logistic回归分析显示Hcy为CAD独立危险因素(OR=1.331,95%CI:1.115~1.589,P=0.002)。Hcy及SCr随Gensini积分增加而升高,Hcy和SCr水平同Gensini积分呈正相关性(P<0.05)。结论Hcy、SCr与CAD冠状动脉病变严重程度呈正相关。Objective To analyze the correlation between serum homocysteine(Hcy),serum creatinine(SCr)levels and the severity of coronary artery disease in patients with coronary atherosclerotic heart disease(CAD).Methods Collected the information of 146 patients who underwent coronary artery angiography operation in the cardiology department from February 2018 to February 2019,and they were divided into the CAD group and the non-CAD group according to the results of angiography.Compared the general clinical data of the two groups,calculated the Gensini score,and analyzed the correlation between Hcy,SCr levels and Gensini score.Results The levels of Hcy and SCr in the CAD group were higher than those in the non-CAD group(P<0.05).Binary logistic regression analysis showed that Hcy was an independent risk factor for CAD(OR=1.331,95%CI:1.115-1.589,P=0.002).Hcy and SCr increased with the increasing of Gensini score,Hcy and SCr levels had a positive correlation with Gensini score(P<0.05).Conclusion Hcy and SCr are positively correlated with the severity of CAD.

关 键 词：冠心病 半胱氨酸 肌酸酐 GENSINI评分 LOGISTIC模型 相关性 

分 类 号：R543.3[医药卫生—心血管疾病]