慢性阻塞性肺疾病患者IL-8、LTB4、PGE2水平及与肺功能受损严重程度的相关性  

Correlation between IL-8,LTB4 and PGE2 expression and severity of pulmonary function impairment in patients with chronic obstructive pulmonary disease

作　　者：李霞[1] 荣庆娜 江丽娟 王欢[1] Xia Li;Qing-na Rong;Li-juan Jiang;Huan Wang(Respiratory Department,People’s Hospital of Langfang City,Langfang,Hebei 065000,China)

机构地区：[1]廊坊市人民医院呼吸科,河北廊坊065000

出　　处：《中国现代医学杂志》2020年第18期18-21,共4页China Journal of Modern Medicine

基　　金：河北省科技支撑计划项目(No:12277732)。

摘　　要：目的探究白细胞介素-8(IL-8)、白三烯B4(LTB4)、前列腺素E2(PGE2)在慢性阻塞性肺疾病(COPD)患者中的表达水平及与肺功能受损严重程度的相关性。方法前瞻性选择2018年5月—2019年5月廊坊市人民医院收治的98例急性期COPD患者作为病例组,另取同期该院健康体检者50例作为对照组。比较两组血清IL-8、LTB4、PGE2水平,比较不同肺功能受损严重程度患者血清IL-8、LTB4、PGE2水平,分析其与肺功能受损严重程度的相关性,采用多因素Logistic回归分析COPD的影响因素。结果病例组血清IL-8、LTB4、PGE2水平高于对照组(P<0.05)。不同肺功能受损严重程度患者血清IL-8、LTB4、PGE2水平比较,差异有统计学意义(P<0.05),Ⅳ级>Ⅲ级>Ⅱ级>Ⅰ级。COPD患者血清IL-8、LTB4、PGE2水平与肺功能受损严重程度均呈正相关(r_s=0.712、0.561、和0.476,P<0.05)。血清IL-8[OlR=2.268(95% CI:1.272,3.948)]、LTB4[OlR=1.847(95% CI:1.161,2.746)]、PGE2[OlR=2.108(95% CI:1.202,3.326)]是COPD的危险因素(P<0.05)。结论 IL-8、LTB4、PGE2在COPD患者血清中高表达,与COPD发生及肺功能受损严重程度相关,有望成为预测COPD发生、发展的指标之一。Objective To investigate the correlation between interleukin-8(IL-8),leukotriene B4(LTB4)and prostaglandin E2(PGE2)expression and severity of pulmonary function impairment in patients with chronic obstructive pulmonary disease(COPD).Methods Ninety-eight acute COPD patients(case group)and 50 physical examinees(control group)in our hospital from May 2018 to May 2019 were selected.Serum IL-8,LTB4,and PGE2 levels were detected,and then the comparison was made between groups and among COPD patients with different severity of pulmonary function impairment.Spearman correlation analysis was used to analyze the correlation between IL-8,LTB4 and PGE2 expression and severity of pulmonary function impairment.Multivariate logistic regression was used to analyze the influencing factors of COPD.Results The levels of serum IL-8,LTB4 and PGE2 in the case group were significantly higher than those in the control group(P<0.05).Among all patients,serum IL-8,LTB4,and PGE2 levels were highest in patients with gradeⅣpulmonary function impairment,followed by the gradeⅢ,grade II and grade I,and paired comparison showed statistic differences(P<0.05).Serum IL-8,LTB4,and PGE2 levels were positively correlated with the severity of pulmonary function impairment(rs=0.712,0.561,0.476,P<0.05)and were independent risk factors for COPD[OlRIL-8=2.268(95%CI:1.272,3.948);OlRLTB4=1.847(95%CI:1.616,2.746);OlRPGE2=2.108(95%CI:1.202,3.326)](P<0.05).Conclusions IL-8,LTB4 and PGE2 are highly expressed in serum of COPD patients and significantly correlated with the severity of pulmonary function impairment in COPD,and potentially can be established as reliable predictors of the occurrence and development of COPD.

关 键 词：肺疾病 慢性阻塞性 白细胞介素-8 白三烯B4 前列腺素E2 肺功能 相关性 

分 类 号：R563.9[医药卫生—呼吸系统]