颈动脉斑块超声造影及hs-CRP与急性脑梗死体积关系的研究  

The Relationship Between Carotid Plaque Contrast-enhanced Ultrasound and hs-CRP and the Volume of Acute Cerebral Infarction

作　　者：聂红军[1] 李芬穗[1] 胡珏[2] 李建[1] 罗小艳 张敏 Nie Hongjun;Li Fensui;Hu Jue;Li Jian;Luo Xiaoyan;Zhang Min(Department of Ultrasound,Changsha Central Hospital,Changsha,Hunan 410007,China)

机构地区：[1]长沙市中心医院超声科,长沙市410007 [2]长沙市中心医院神经内科,长沙市410007

出　　处：《中国超声医学杂志》2020年第8期687-690,共4页Chinese Journal of Ultrasound in Medicine

基　　金：长沙市科技局科研项目(No.kq1701002)。

摘　　要：目的探讨颈动脉斑块超声造影及血清超敏C反应蛋白(hs-CRP)水平与急性脑梗死体积的关系。方法选取我院颈动脉斑块患者90例,根据有无合并脑梗死分为急性脑梗死组55例、非脑梗死组35例。所有患者行颈动脉超声和斑块超声造影,根据脑梗死体积将脑梗死组分为大体积和中小体积脑梗死组。检测比较各组斑块厚度、斑块造影峰值强度(PI)及血清hs-CRP水平。结果脑梗死组与非脑梗死组的斑块造影PI、血清hs-CRP水平比较差异具有统计学意义(P<0.05)。大体积脑梗死组与中小体积脑梗死组的斑块造影PI、血清hs-CRP水平比较差异具有统计学意义(P<0.05)。脑梗死组斑块造影PI、血清hs-CRP均与脑梗死体积大小存在线性关系。结论颈动脉斑块超声造影PI和血清hs-CRP水平与急性脑梗死发生及梗死体积大小有关,颈动脉斑块超声造影及血清hs-CRP水平有助于预测脑梗死的发生及预后。Objective To investigate the relationship between carotid plaque contrast-enhanced ultrasound(CEUS),the levels of serum high-sensitivity C-reactive protein(hs-CRP)and the volume of acute cerebral infarction.Methods 90 inpatients with carotid plaques were selected and divided into the acute cerebral infarction group(n=55)and the non-cerebral infarction group(n=35).All patients underwent carotid ultrasound and carotid plaque CEUS.According to the size of cerebral infarction volume,the acute cerebral infarction groups were divided into the large volume cerebral infarction subgroup and small and medium volume cerebral infarction subgroup.The plaque thickness,peak intensity(PI)of CEUS and serum hs-CRP levels were measured.Results There were significant differences in PI of carotid plaque CEUS and serum hs-CRP levels between the cerebral infarction group and the non-cerebral infarction group(P<0.05).The differences in PI of carotid plaque CEUS and serum hs-CRP between the large volume cerebral infarction subgroup and the small and medium volume cerebral infarction subgroup were statistically significant(P<0.05).There was a linear correlation between PI of carotid plaque CEUS and serum hs-CRP levels and cerebral infarction volume in the cerebral infarction group.Conclusions PI of carotid plaque CEUS and serum hs-CRP levels are related to the occurrence of acute cerebral infarction and the size of infarct volume.Carotid plaque contrast-enhanced ultrasound and serum hs-CRP levels are helpful to predict the occurrence and prognosis of cerebral infarction.

关 键 词：脑梗死 颈动脉斑块 超声造影 峰值强度 超敏C反应蛋白 

分 类 号：R445.1[医药卫生—影像医学与核医学] R743.3[医药卫生—诊断学]