绿色连续合成对三氟甲基苯酚  

Green Continuous Synthesis of 4-Trifluoromethylphenol

作　　者：张泉泉 卜健鸿 赵红英 吕钟楠 ZHANG Quan-quan;BU Jian-hong;ZHAO Hong-ying;LV Zhong-nan(Zhejiang Weihua New Materials Co.,Ltd.,Shaoxing,Zhejiang 312300,China;Zhejiang Weihua Chemical Co.,Ltd.,Dongyang,Zhejiang 322109,China)

机构地区：[1]浙江巍华新材料股份有限公司,浙江绍兴312300 [2]浙江巍华化工有限公司,浙江东阳322109

出　　处：《浙江化工》2020年第8期16-18,共3页Zhejiang Chemical Industry

摘　　要：以对三氟甲基苯胺为起始原料,采用微通道连续化法重氮化、管式水解合成对三氟甲基苯酚,反应收率达92.4%,纯度为99.6%,避免了催化剂硫酸铜的使用。该连续流合成对三氟甲基苯酚工艺方法绿色环保,可工业化。Using 4-aminobenzotrifluoride as the starting material,4-trifluoromethylphenol was synthesized by microchannel continuous diazotization and tubular hydrolysis.The reaction yield was 92.4%and the purity was 99.6%.The use of copper sulfate as catalyst was avoided.The continuous flow synthesis of 4-trifluoromethylphenol is green and environmental friendly,and can be industrialized.

关 键 词：对三氟甲基苯胺 对三氟甲基苯酚 微通道反应器 连续流 

分 类 号：O625.312[理学—有机化学]