呼吸道合胞病毒感染患儿并发喘息的危险因素  

Risk factors for wheezing in children with respiratory syncytial virus infection

作　　者：孟祥菲 王晓娜[1] MENG Xiang-fei;WANG Xiao-na(First Hospital of Jilin University,Changchun,Jilin 130021,China)

机构地区：[1]吉林大学第一医院小儿心血管风湿免疫护理平台,吉林长春130021

出　　处：《中华医院感染学杂志》2020年第13期2053-2057,共5页Chinese Journal of Nosocomiology

基　　金：吉林市医药科技攻关计划基金资助项目(3624622)。

摘　　要：目的探讨呼吸道合胞病毒感染患儿并发喘息的危险因素。方法收集2016年6月-2019年4月吉林大学第一医院收治的2381例呼吸道合胞病毒感染所致急性下呼吸道感染患儿的临床资料,其中108例患儿发生喘息,作为喘息组,同期选取来医院体检的健康儿童100名,作为对照组。采用酶联免疫吸附法检测两组血清白介素(IL)-6、IL-1β、降钙素原(PCT)变化,运用单因素及多因素Logistic回归分析方法对患儿可能发生喘息的危险因素进行统计分析,比较所有患儿胸片中的病变状况。结果与对照组相比,喘息组患儿血清IL-6、IL-1β、PCT表达水平上升(P<0.05)。单因素分析结果显示呼吸道合胞病毒感染所致急性下呼吸道感染患儿的年龄、性别、是否为特应征体质与喘息发生有关;多因素Logistic回归分析结果显示,发病年龄小、男性、特应性体质是呼吸道合胞病毒感染所致急性下呼吸道感染患儿并发喘息的高危因素,急性下呼吸道感染患儿并发喘息患儿的胸片与未并发喘息患儿比较,具有统计学差异(P<0.05)。结论呼吸道合胞病毒感染所致急性下呼吸道感染患儿喘息发生受多因素影响,临床应根据这些高危因素加强预防措施以减少患儿并发喘息的发病率。OBJECTIVE To explore the risk factors for wheezing in the children with respiratory syncytial virus infection.METHODS The clinical data were collected from 2381 children who had acute lower respiratory tract infection caused by respiratory syncytial virus infection admitted to the First Hospital of Jilin University from Jun.2016 to Apr.2019,108 of whom had wheezing and were assigned as the wheezing group,meanwhile,100 healthy children who received physical examination were set as the control group.The levels of serum interleukin-6(IL-6),IL-1βand procalcitonin(PCT)of the two group were detected by using enzyme-linked immunosorbent assay,the risk factors for wheezing in the children were statistically analyzed by means of univariate analysis and multivariate logistic regression analysis,and the lesions in the chest imaging were compared among the children.RESULTS The levels of serum IL-6,IL-1βand PCT of the wheezing group were significantly higher than those of the control group(P<0.05).The result of univariate analysis showed that the wheezing in the children with acute lower respiratory tract infection induced by the respiratory syncytial virus infection was associated with the age,gender and specially applicable physique;the result of multivariate logistic regression analysis indicated that the young age,male and specially applicable physique were the high risk factors for the wheezing in the children with acute lower respiratory tract infection induced by the respiratory syncytial virus infection,and there were significant differences in the chest imaging findings between the acute lower respiratory tract infection children complicated with wheezing and the children without wheezing(P<0.05).CONCLUSION There are a variety of influencing factors for the wheezing in the children with acute lower respiratory tract infection induced by the respiratory syncytial virus infection.It is necessary for the hospital to strengthen the prevention measures according to the high risk factors so as to reduce the incidence of

关 键 词：呼吸道合胞病毒感染 急性下呼吸道感染 并发喘息 危险因素 LOGISTIC回归分析 

分 类 号：R725.6[医药卫生—儿科]