益肾促排卵汤联合西药治疗排卵障碍性不孕临床研究  

Clinical Study on Yishen Cupailuan Tang Combined with Western Medicine for Infertility Due to Ovulation Dysfunction

作　　者：张红彩 张红晓 ZHANG Hongcai;ZHANG Hongxiao

机构地区：[1]平煤神马集团十三矿医院,河南平顶山467000

出　　处：《新中医》2020年第14期99-102,共4页New Chinese Medicine

摘　　要：目的:观察益肾促排卵汤联合西药治疗排卵障碍性不孕的临床疗效。方法:选取134例排卵障碍性不孕患者,按随机数字表法分为对照组和观察组各67例。对照组予以枸橼酸氯米芬胶囊及绒促性素治疗,观察组在此基础上加服益肾促排卵汤。对比2组临床疗效、卵泡发育情况、子宫内膜厚度、宫颈黏液评分及卵巢血流指标。结果:观察组排卵率、未破裂卵泡黄素化综合征(LUFS)发生率及宫颈黏液评分>8分患者所占比例均高于对照组(P<0.05)。治疗后,2组排卵日子宫内膜厚度均增大(P<0.05),观察组排卵日子宫内膜厚度大于对照组(P<0.05)。治疗后,2组卵巢动脉阻力指数(RI)、搏动指数(PI)、收缩期峰值流速/舒张末期血流速度(S/D)值均较治疗前减小(P<0.05),观察组卵巢动脉RI、PI和S/D值均小于对照组(P<0.05)。观察组总有效率为92.54%,高于对照组的76.12%(P<0.05)。结论:益肾促排卵汤联合西药治疗排卵障碍性不孕,可有效改善患者的卵泡质量及卵巢动脉血流,促进子宫内膜生长,提高排卵率及妊娠率,减少LUFS发生。Objective:To observe the clinical effect of Yishen Cupailuan tang combined with infertility due to ovulation dysfunction. Methods: A total of 134 cases of patients with infertility due to ovulation dysfunction were divided into the control group and the observation group according to the random number table method,67 cases in each group. Both groups were treated with clomifene citrate capsules and chorionic gonadotrophin,and the observation group was additionally treated with Yishen Cupailuan tang based on the treatment group. The clinical effect,follicular development,endometrial thickness,the scores of cervical mucus and the indexes of ovary blood flow were compared between the two groups. Results:The ovulation rate,the incidence of luteinizing unruptured follicle syndrome(LUFS) and the percentage of cervical mucus score which is higher than eight in the observation group were all higher than those in the control group(P<0.05). After treatment,the endometrial thickness on the day of ovulation in the two groups was increased(P<0.05), and the thickness in the observation group was larger than that in the control group(P<0.05). After treatment,the resistance indexes(RI),pulsatility indexes(PI) and systolic peak velocity/diastolic end velocity(S/D) of ovarian artery in the two groups were decreased when compared with those before treatment(P<0.05),and the above values in the observation group were all lower than those in the control group(P<0.05). The total effective rate was 92.54% in the observation group,higher than that of 76.12% in the control group(P<0.05). Conclusion: The therapy of Yishen Cupailuan tang combined with western medicine in treating infertility due to ovulation dysfunction,which can effectively improve follicular quality and ovary artery blood flow,promote the growth of endometrium,enhance ovulation rate and pregnancy rate,and reduce the incidence of LUFS.

关 键 词：排卵障碍性不孕 益肾促排卵汤 卵泡质量 子宫内膜 卵巢动脉血流 未破裂卵泡黄素化综合征 

分 类 号：R711.6[医药卫生—妇产科学]