美托洛尔联合丹红注射液对老年慢性心力衰竭患者血清GDF-15、NT-proBNP、ICAM-1、β-EP水平的影响  

Effects of Metoprolol Combined with Danhong Injection on the Levels of Serum GDF-15,NT proBNP,ICAM-1 andβ-EP in Elderly Patients with Chronic Heart Failure

作　　者：苏金虎 张勇 李斌儒 刘睿 牛津 SU Jin-hu;ZHANG Yong;LI Bin-ru;LIU Rui;NIU Jin(Joint Logistics Support Unit 940 Hospital,Stationed in the second outpatient department,Lanzhou,Gansu,730000,China;Joint Logistics Support Unit 940 Hospital,Stationed in the first outpatient department,Lanzhou,Gansu,730000,China;Joint Logistics Support Unit 940 Hospital,Nutrition departments,Lanzhou,Gansu,730000,China;Joint Logistics Support Unit 940 Hospital,Cadre wards,Lanzhou,Gansu,730000,China)

机构地区：[1]联勤保障部队第九四〇医院第二派驻门诊部,甘肃兰州730000 [2]联勤保障部队第九四〇医院第一派驻门诊部,甘肃兰州730000 [3]联勤保障部队第九四〇医院营养科,甘肃兰州730000 [4]联勤保障部队第九四〇医院干部病房,甘肃兰州730000

出　　处：《现代生物医学进展》2020年第13期2520-2523,共4页Progress in Modern Biomedicine

基　　金：国家卫生计生委医药卫生科技发展项目(W2015CAE173)。

摘　　要：目的:研究美托洛尔联合丹红注射液对老年慢性心力衰竭患者血清生长分化因子-15(Growth differentiation factor-15,GDF-15)、前体N末端前脑利钠肽(Pro N-terminal pro brain natriuretic peptide,NT-pro BNP)、细胞黏附分子-1(Cell adhesion molecule-1,ICAM-1)、β内啡肽(Beta endorphin,β-EP)水平的影响。方法:选择2015年10月~2019年9月我院收治的328例老年慢性心力衰竭患者,随机分为两组。对照组口服美托洛尔,初始剂量为每次6.25 mg,每天2次,慢慢增加至每次12.5 mg,每天2次;观察组在美托洛尔的基础上,静脉滴注丹红注射液,每次20 mL,每天1次。均治疗1个月。结果:观察组的有效率明显高于对照组(P<0.05);治疗后,两组的左心室舒张期末内径(End diastolic diameter of left ventricle,LVEDD)、6 min步行试验(6MWT)、左心室射血分数(Left ventricular ejection fraction,LVEF)、左心室收缩期末内径(Left ventricular end systolic diameter,LVESD)均明显改善,且观察组的LVEDD、6MWT、LVEF、LVESD明显优于对照组(P<0.05);治疗后,两组的血清GDF-15、NT-proBNP、ICAM-1、β-EP水平明显降低(P<0.05),且观察组的血清GDF-15、NT-proBNP、ICAM-1、β-EP水平明显低于对照组(P<0.05)。结论:美托洛尔联合丹红注射液对老年慢性心力衰竭具有显著的疗效,其机制可能与降低血清GDF-15、NT-proBNP、ICAM-1、β-EP水平有关。Objective:To study the effects of metoprolol combined with Danhong Injection on serum growth differentiation factor-15(GDF-15),pro N-terminal pro brain natriuretic peptide(NT Pro BNP),cell adhesion molecule-1(ICAM-1),beta endorphin(β-EP)in elderly patients with chronic heart failure.Methods:Selected 328 cases of elderly patients with chronic heart failure who were treated in our hospital from October 2015 to September 2019,divided into two groups randomly.In the control group,metoprolol was taken orally,the initial dose was 6.25 mg per time,twice a day,slowly increased to 12.5 mg per time,twice a day.In the observation group,on the basis of metoprolol,Danhong injection was infused intravenously,20 mL each time,once a day.All patients were treated for one month.Results:The effective rate of the observation group was significantly higher than control group(P<0.05).After treatment,the LVEDd,6MWT,LVEF and LVESD of the two groups were significantly improved,and the LVEDd,6MWT,LVEF and LVESD of the observation group were significantly better than those of the control group(P<0.05).After treatment,the levels of serum GDF-15,NT proBNP,ICAM-1 andβ-EP in the two groups decreased significantly(P<0.05),the levels of GDF-15,NT proBNP,ICAM-1 andβ-EP in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Metoprolol combined with Danhong injection has a significant effect on chronic heart failure in the elderly.The mechanism may be related to the decrease of serum GDF-15,NT proBNP,ICAM-1 andβ-EP levels.

关 键 词：美托洛尔 丹红注射液 慢性心力衰竭 生长分化因子-15 前体N末端前脑利钠肽 细胞黏附分子-1 Β内啡肽 

分 类 号：R541.61[医药卫生—心血管疾病]