免疫介导的感音神经性听力损失患病率及治疗策略  

Immune-mediated sensorineural hearing loss:prevalence and treatment strategies

作　　者：李熙星 陈雨濛 张光远 崔卫娜[1] LI Xixing;CHEN Yumeng;ZHANG Guangyuan

机构地区：[1]河北医科大学第二医院耳鼻咽喉头颈外科,石家庄050000

出　　处：《临床耳鼻咽喉头颈外科杂志》2020年第7期663-667,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：1958年Lehnhardt[1]首次描述了进行性双侧感音神经性听力损失(sensorineural hearing loss,SNHL)患者的抗原抗体反应,推测双耳突聋的病因可能是一种免疫反应。1979年,McCabe基于对18例进行性SNHL患者的临床观察和实验室检查,首次提出了"自身免疫性SNHL"这一新的疾病实体概念,考虑到自身免疫性损害不仅累及耳蜗和听神经,亦可波及前庭,又将其称为"自身免疫性内耳病"。Autoimmune sensorineural hearing loss is a rare clinical entity which accounting for less than 1%in all cases with hearing loss.The prevalence of hearing loss in immune-mediated inner ear diseases,as shown in case reports or single-center statistics,varies widely.We reviewed the current literatures on the association between sensorineural hearing loss and autoimmune diseases,focused on the prevalence of hearing loss in different autoimmune diseases,treatments and challenges.

关 键 词：听觉丧失 感音神经性 自身免疫性内耳病 人工耳蜗植入 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]