老年高血压前期患者血管内皮功能的临床研究  

A clinical study of vascular endothelial function in elderly people with prehypertension

作　　者：田相亭 杨辉剑 郑猛 陈勇池 Tian Xiangting;Yang Huijian;Zheng Meng;Chen Yongchi(Department of Cardiology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangdong Provincial Geriatrics Institute,Guangzhou 510080,China)

机构地区：[1]广东省人民医院广东省医学科学院广东省老年医学研究所心内科,广州510080

出　　处：《中华老年医学杂志》2020年第8期879-882,共4页Chinese Journal of Geriatrics

基　　金：广东省医学科研基金项目(A2016548)。

摘　　要：目的研究生活方式和伊贝沙坦干预对老年高血压前期者血管内皮功能的影响。方法 70例老年高血压前期者随机分为生活方式干预组及伊贝沙坦干预组,观察1年,比较二组干预前后循环内皮细胞微颗粒(EMPS)水平及肱-踝脉搏波传导速度(baPWV)水平的变化。结果生活方式干预前后循环EMPs[(1 946±234)个/μl和(1 745±416)个/μl,t=2.530、P=0.011]水平及baPWV[(1 653±172)cm/s和(1 511±230)cm/s,t=2.448、P=0.017]水平比较差异均有统计学意义;伊贝沙坦干预前后循环EMPs[(19 507±146)个/μl和(1 446±286)个/μl,t=3.340、P=0.002]水平及baPWV[(1 639±165)cm/s和(1 361±211)cm/s,t=3.156、P=0.005]比较差异均有统计学意义;1年后伊贝沙坦干预组循环EMPs水平及baPWV水平与生活方式干预组比较有统计学差异(t=2.238、2.475,均P<0.05)。结论老年高血压前期者生活方式干预和伊贝沙坦干预对血管内皮功能都有保护作用,延缓动脉粥样硬化的发生和发展;伊贝沙坦干预较生活方式干预对血管内皮功能保护作用,延缓动脉粥样硬化的发生和发展效果更明显。Objective To study the effect of lifestyle intervention and Irbesartan intervention on vascular endothelial function in elderly people with prehypertension.Methods Seventy elderly people with prehypertension were randomly divided into the lifestyle intervention group and the Irbesartan intervention group.After one year of intervention,the level of cyclic endothelial microparticles(EMPs)and brachial-ankle pulse wave conduction velocity(baPWV)before and after the intervention were compared between the two groups.Results There were significant differences in levels of circulating EMPs[(1 946±234)/μl.(1745±416)/μl,t=2.530,P=0.011]and baPWV[(1653±172)cm/s vs.(1511±230)cm/s,t=2.448,P=0.017]bef0re and after one year of lifestyle intervention.There were also significant differences in levels of circulating EMPsC(19507i 146)/μl vs.(1446±286)/μl,t=3.340,P=0.002]and baPWV[(1639±165)cm/s vs.(1361±211)cm/s,t=3.156,P=0.005]before and after one year of Irbesartan intervention and between the lifestyle intervention group and the Irbesartan intervention group after one year(r=2.238 and 2.475,P<0.05).Conclusions Lifestyle intervention and Irbesartan intervention have protective effects on vascular endothelial function and delay the initiation and progression of atherosclerosis in elderly people with prehypertension,and irbesartan intervention is more effective than lifestyle intervention.

关 键 词：高血压 内皮血管 

分 类 号：R544.1[医药卫生—心血管疾病]