糖皮质激素对子代卵巢发育影响及其宫内编程机制  

Effects of glucocorticoids on ovarian development of offspring and its intrauterine programming mechanism

作　　者：樊冠兰 吕丰 张蔚[1] 汪晖[1] Fan Guanlan;Lyu Feng;Zhang Wei;Wang Hui(Department of Obstetrics and Gynecology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China;Department of Pharmacology,Basic Medical School of Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院妇产科,430071 [2]武汉大学基础医学院药理学系,430071

出　　处：《中华生殖与避孕杂志》2020年第7期605-609,共5页Chinese Journal of Reproduction and Contraception

基　　金：国家自然科学基金重点项目(81430089);国家自然科学基金面上项目(81673524,81671472)。

摘　　要：孕期的各种应激刺激及临床上地塞米松等药物的广泛使用是导致胎儿暴露于内、外源性糖皮质激素的重要原因。女性(雌性)卵巢功能异常甚至疾病状态具有宫内起源,而糖皮质激素可能参与编程子代卵巢功能发育损伤甚至多代的功能异常。本综述结合临床和实验室的研究进展,系统概述内、外源性糖皮质激素导致子代卵巢发育损伤及其多代遗传的现象,并初步探讨其宫内编程机制。During pregnancy,stress stimulation and the widespread use of drugs(such as dexamethasone)are the important causes of fetus exposed to endogenous and exogenous glucocorticoids.Ovarian dysfunction and some reproductive endocrine disorders have intrauterine origin.And the abnormal ovarian functional development in offspring could be programmed by glucocorticoids,which even has multigenerational effects.This article systematically reviews the damage of ovarian development and multigenerational phenotype of offspring caused by endogenous and exogenous glucocorticoids,as well as summarizing the potential intrauterine mechanism according to clinical and laboratory studies.

关 键 词：孕期糖皮质激素暴露 卵巢发育 宫内编程 

分 类 号：R711.75[医药卫生—妇产科学]