聚ε-己内酯-b-聚乙二醇-b-聚ε-己内酯静电组装产物形态的初步考察  

Preliminary Study onε-the Morphology of Electrostatic Assembly Products of Poly(ε-)-caprolactone-b-polyethylene Glycol-polycaprolactone

作　　者：董欣 刘阳 黄佳娜 王浩 Dong Xin;Liu Yang;Huang Jiana;Wang Hao(School of Pharmacy,Jinzhou Medical University,Jinzhou 121000 China;Shandong Key Laboratory of Medical Polymer Materials,Shandong Academy of Pharmacy,Jinan 370102 China)

机构地区：[1]锦州医科大学药学院,辽宁锦州121000 [2]山东省医用高分子材料重点实验室,山东省药学科学院,山东济南370102

出　　处：《锦州医科大学学报》2020年第4期5-11,共7页Journal of Jinzhou Medical University

基　　金：辽宁省药物作用与质量评价工程技术中心主任基金,项目编号:2018110605;辽宁省大学生创新基金,项目编号:201710160000228;山东省重点研发计划项目,项目编号:2017GSF18168。

摘　　要：目的考察分子量15kDa以下的聚ε-己内酯-b-聚乙二醇-b-聚ε-己内酯静电组装产物的形态。方法以2kDa和4kDa两种两端羟基聚乙二醇为引发剂引发ε-己内酯开环聚合,得到聚ε-己内酯嵌段不同的4种聚合物。以二氯甲烷或二氯甲烷-N,N二甲基甲酰胺为溶剂溶解之并静电组装。扫描电子显微镜观察所得产物形态。结果静电组装产物有不规则团块、桑葚、球三种结构。随着分子量增加和溶液浓度变高,体系从不规则团块状向桑葚状或球状结构转变。结论聚ε-己内酯-b-聚乙二醇-b-聚ε-己内酯静电组装可以得到多种形态产物,受溶液浓度和分子量的影响。Objective To investigate the morphology of static electro-assembling products of polyε-caprolacton e-b-polyethylene glycol-b-polyε-caprolactone with molecular weights under 15kDa.Methods Ring-opening polymerization ofε-caprolactone was initiated by 2kDa and 4kDa two-terminal hydroxyl polyethylene glycols as initiators.Four kinds of polymers with different polyε-caprolactone blocks were obtained.Dichloromethane or mixture of dichloromethane-N,N dimethylformamide were used as the solvent to dissolve the copolymers for static electric-assembling.Morphology of obtained products was observed by a scanning electron microscope.Results The static electro-assembling products presented three kinds of structures which were irregular conglomeration,mulberry and sphere.As molecular weights increased and solution concentration became higher,the system changed from irregular conglomerations to mulberry-like or sphere structures.Conclusion Various morphological products can be obtained by polyε-caprolactone-b-polyethylene glycol-b-polyε-caprolactone static electro-assembling,which are affected by concentration and molecular weight of solution.

关 键 词：静电组装 聚Ε-己内酯 聚乙二醇 嵌段共聚物 微球 

分 类 号：R912[医药卫生—药学]