过氧化氢联合甲硝唑宫腔冲洗治疗产褥感染患者的效果  

Effect of Hydrogen Peroxide Combined with Metronidazole Uterine Cavity Irrigation in the Treatment of Patients with Puerperal Infection

作　　者：周菊[1] 邹昌军 王榀华[1] 白雪[1] ZHOU Ju;ZOU Chang-jun;WANG Pin-hua;BAI Xue(Department of Obstetrics,Qinghai Red Cross Hospital,Xining 810000,Qinghai,China;Department of Obstetrics,Subject Two,Handan Maternal and Child Health Hospital,Handan 056000,Hebei,China)

机构地区：[1]青海红十字医院产科,青海西宁810000 [2]邯郸市妇幼保健院产二科,河北邯郸056000

出　　处：《医学信息》2020年第16期154-155,158,共3页Journal of Medical Information

摘　　要：目的探讨过氧化氢联合甲硝唑宫腔冲洗治疗产褥感染患者的临床疗效。方法选择我院2018年5月~2019年5月收治的69例产褥感染患者,按照随机数字表法分为观察组(35例)和对照组(34例)。对照组给予青霉素钠联合氨苄西林冲洗,观察组给予过氧化氢联合甲硝唑宫腔冲洗,比较两组临床疗效、发热消退时间、症状消失时间、住院时间、血清指标[血清C反应蛋白(CRP)、降钙素原(PCT)、白细胞介素-6(IL-6)、血沉(ESR)]。结果观察组总有效率为97.14%,高于对照组的85.29%,差异有统计学意义(P<0.05)。观察组发热消退时间、症状消失时间、住院时间均低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组CRP、PCT、IL-6、ESR1低于对照组,差异有统计学意义(P<0.05)。结论过氧化氢联合甲硝唑宫腔冲洗治疗产褥感染临床疗效确切,可有效缩短患者治疗时间及住院时间,降低炎性因子水平,抑制细菌生长繁殖。Objective To investigate the clinical effect of hydrogen peroxide combined with metronidazole intrauterine irrigation in the treatment of patients with puerperal infection.Methods A total of 69 patients with puerperal infection admitted to our hospital from May 2018 to May 2019 were selected and divided into observation group(35 cases)and control group(34 cases)according to the random number table method.The control group was given penicillin sodium combined with ampicillin flushing,and the observation group was given hydrogen peroxide combined with metronidazole intrauterine flushing.The two groups were compared with the clinical efficacy,fever subsidence time,symptom disappearance time,hospital stay,serum index[serum C-reactive protein(CRP),procalcitonin(PCT),interleukin-6(IL-6),erythrocyte sedimentation rate(ESR)].Results The total effective rate of the observation group was 97.14%,which was higher than 85.29% of the control group,the difference was statistically significant(P<0.05).The time of fever subsidence,time of symptom disappearance,and hospitalization time of the observation group were lower than those of the control group,the difference was statistically significant(P<0.05).After treatment,CRP,PCT,IL-6 and ESR1 in the observation group were lower than those in the control group,the difference was statistically significant(P<0.05).Conclusion Hydrogen peroxide combined with metronidazole uterine cavity irrigation has a definite clinical effect in the treatment of puerperal infection,which can effectively shorten the treatment time and hospital stay of patients,reduce the level of inflammatory factors,and inhibit the growth and reproduction of bacteria.

关 键 词：甲硝唑 宫腔冲洗 产褥感染 厌氧菌 

分 类 号：R716.62[医药卫生—妇产科学]