股骨头坏死动物模型的造模方法及特点  

Animal models of osteonecrosis of the femoral head:modeling methods and characteristics

作　　者：王岩[1] 董本超 王颖[1] 孙磊[1] 卢斌 柏豪豪 田爱现 马剑雄[1] 马信龙[1] Wang Yan;Dong Benchao;Wang Ying;Sun Lei;Lu Bin;Bai Haohao;Tian Aixian;Ma Jianxiong;Ma Xinlong(Orthopaedics Institute,Tianjin Hospital,Tianjin University(Tianjin Hospital),Tianjin 300050,China)

机构地区：[1]天津大学天津医院(天津市天津医院)骨科研究所,天津市300050

出　　处：《中国组织工程研究》2021年第2期292-297,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(11772226),项目负责人:马剑雄;中国博士后科学基金面上资助(2017M621087),项目负责人:马剑雄;天津市卫生局科技攻关项目(15KG123),项目负责人:马信龙;天津市卫生局科技攻关项目(2014KY31),项目负责人:马剑雄;天津市博士后创新项目择优资助项目(TJQYBSH2017017),项目负责人:马剑雄。

摘　　要：背景:股骨头坏死是骨伤科常见的疑难病症,致残率高,目前对于其发病机制仍然没有一个明确的定论,也未找到彻底治愈该疾病的理想方法。因此,需要借助动物模型来进一步研究该疾病的病因、发病机制、治疗方法等。目的:综述近年来常用的一些股骨头坏死动物模型,总结分析出每一类动物模型对应的临床症状和模型的优缺点,从而为后续研究提供基础。方法:以"股骨头坏死,动物模型,femoral head necrosis,animal model"等为检索关键词,在万方、维普、中国知网、PubMed、Embase、Medline等数据库中检索2000年1月至2019年12月的文献,根据标准最终纳入42篇参考文献。结果与结论:①股骨头坏死动物模型已经用于相关研究多年,这确实提高了对此类骨科疾病的理解和研究;②但是目前股骨头坏死的相关研究仍然需要进一步深入探索,通过建立更理想、更完善的动物模型可在该研究领域实现新的突破。BACKGROUND:Osteonecrosis of the femoral head is a common and difficult disease in orthopedic department,with a high disability rate.At present,there is still no clear conclusion about its pathogenesis,as well as no ideal way to cure the disease.Therefore,it is necessary to use animal models to further study the etiology,pathogenesis and treatment of the disease.OBJECTIVE:To review some common animal models of osteonecrosis of the femoral head in recent years,summarize and analyze the corresponding clinical symptoms and the advantages and disadvantages of each animal model,so as to provide the basis for the follow-up research in this area.METHODS:The keywords of“femoral head necrosis”and“animal model”were used to search articles published between January 2000 to December 2019 in WanFang,VIP,CNKI,PubMed,Embase and Medline databases.Finally 42 eligible articles were included.RESULTS AND CONCLUSION:The animal model of osteonecrosis of the femoral head has been used for many years,which really improves the understanding and research of this kind of orthopedic disease.However,at present,the related research of such diseases still needs to be further explored,through the establishment of more ideal and perfect animal models to achieve a new breakthrough in this research field.

关 键 词：骨 股骨 股骨头坏死 动物模型 造模 综述 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]