三种感冒药片微量元素的LIBS检测  

Determination of Trace Elements in Three Cold Medicine Tablets by Laser-Induced Breakdown Spectroscopy

作　　者：傅院霞[1,2] 王莉[1] 徐丽[1] 周彧 FU Yuanxia;WANG Li;XU Li;ZHOU Yu(Department of Science,Bengbu University,Bengbu 233030,China;Anhui Province Key Laboratory of Optoelectronic Materials Science and Technology,Anhui Normal University,Wuhu 241000,China)

机构地区：[1]蚌埠学院理学院,安徽蚌埠233030 [2]安徽师范大学光电材料科学与技术安徽省重点实验室,安徽芜湖241000

出　　处：《大气与环境光学学报》2020年第4期305-313,共9页Journal of Atmospheric and Environmental Optics

基　　金：光电材料科学与技术安徽省重点实验室项目,OMST201703;国家自然科学基金,11604003;安徽省高等学校自然科学研究重点项目,KJ2019A0857。

摘　　要：利用激光诱导击穿光谱技术(Laser-induced breakdown spectroscopy, LIBS),分析了常见感冒药片复方氨酚烷胺分散片、复方氨酚烷胺片(感康)、四季感冒片中的微量元素。波长532 nm的激光聚焦在药片表面产生等离子,通过采集光纤至光谱仪分光,再由增强型电荷耦合器件(Intensified charge-coupled device, ICCD)摄谱,获得三种感冒药片的LIBS光谱。通过对ICCD采集延时和门宽等实验参数的优化获得最佳光谱,检测到氨酚烷胺分散片和四季感冒药中的微量元素有Ca、Mg、Na,复方氨酚烷胺片(感康)中的微量元素有Ca、Mg。由发射光谱线的强度、激发能量、跃迁上能级的权重因子以及跃迁几率,计算得到等离子体的电子温度,研究了激光诱导三种感冒药片等离子体电子温度的时间演化特性。The trace elements of Compound paracetamol and amantadine dispersible tablets,Compound paracetamol and alkylamine tablets(Gankang)and Four seasons cold tablets have been analyzed by Laser-induced Breakdown Spectroscopy(LIBS).The laser with wavelength of 532 nm was focused on the surface of the medicine tablets to generate plasma,and then the spectra of the cold medicine tablets were detected through the collection of optical fiber and spectrometer,and the spectrograph of ICCD.The optimum spectra were obtained by optimizing the acquisition delay and gate width of ICCD.The results show that trace elements of Ca,Mg,Na have been identified in the Compound paracetamol and amantadine dispersible tablets and Four seasons cold tablets,and Ca,Mg have been identified in the Compound paracetamol and alkylamine tablets(Gankang).The electron temperature of plasma were calculated from the intensity of emission spectrum,the excitation energy,statistical weight of the upper levels and the corresponding transition probability of emission spectra.Then the time evolution characteristics of the electron temperature of the plasma induced by laser for the three kinds of cold tablets were studied.

关 键 词：激光诱导击穿光谱技术 感冒药片 微量元素 延迟 门宽 电子温度 

分 类 号：O433.4[机械工程—光学工程]