经鼻高流量加温湿化吸氧治疗COPD并呼吸衰竭的效果及对炎症因子的影响  

Effect of heated humidified high flow nasal cannulaoxygen therapy on COPD complicated with respiratory failure and its influence on inflammatory factors

作　　者：徐汉瑾 张刘杰 XU Hanjin;ZHANG-LIU Jie(the Fourth People's Hospital of Shaanxi,Xi'an 710043,China)

机构地区：[1]陕西省第四人民医院,陕西西安710043

出　　处：《临床医学研究与实践》2020年第24期34-36,共3页Clinical Research and Practice

摘　　要：目的探讨经鼻高流量加温湿化吸氧治疗慢性阻塞性肺疾病(COPD)并呼吸衰竭的效果及对炎症因子的影响。方法将106例COPD并呼吸衰竭患者随机分为对照组和研究组,各53例。对照组实施持续经鼻导管低流量氧气吸入,研究组实施经鼻高流量加温湿化吸氧。比较两组的治疗效果。结果治疗后,研究组的VO2、IL-6、CRP、TNF-α水平低于对照组,CaO2、DO2、SaO2、FEV1、FVC、PEFR均高于对照组(P<0.05)。治疗后,研究组的PaO2、pH均高于对照组,PaCO2、RR均低于对照组(P<0.05)。研究组的治疗总有效率高于对照组(P<0.05)。结论经鼻高流量加温湿化吸氧能显著提高COPD并呼吸衰竭患者的治疗效果,改善患者的肺部功能,减轻炎症反应。Objective To explore the effect of heated humidified high flow nasal cannulaoxygen therapy on chronic obstructive pulmonary disease(COPD)complicated with respiratory failure and its influence on inflammatory factors.Methods A total of 106 patients with COPD complicated with respiratory failure were randomly divided into control group and study group,with 53 cases in each group.The control group received continuous low flow oxygen inhalation through nasal catheter,while the study group received heated humidified high flow nasal cannulaoxygen therapy.The therapeutic effects of the two groups were compared.Results After treatment,the VO2,levels of IL-6,CRP and TNF-αin the study group were lower than those in the control group,while CaO2,DO2,SaO2,FEV1,FVC and PEFR in the study group were higher than those in the control group(P<0.05).After treatment,PaO2 and pH of the study group were higher than those of the control group,PaCO2 and RR were lower than those of the control group(P<0.05).The total effective rate of treatment in the study group was higher than that in the control group(P<0.05).Conclusion Heated humidified high flow nasal cannulaoxygen therapy can significantly improve the treatment effect of COPD patients complicated with respiratory failure,ameliorate the lung function,and reduce the inflammatory reaction.

关 键 词：慢性阻塞性肺疾病 呼吸衰竭 经鼻高流量加温湿化吸氧 

分 类 号：R563[医药卫生—呼吸系统]