初探红外热像对儿童特发性血小板减少性紫癜的诊断价值  

A preliminary study on the diagnostic value of infrared thermography in children with idiopathic thrombocytopenic purpura

作　　者：宓保宏 于存国 宋佳霖[1] 洪文学[1] 张文征[2] 王月[2] MI Baohong;YU Cunguo;SONG Jialin;HONG Wenxue;ZHANG Wenzheng;WANG Yue(College of Electrical Engineering,Yanshan University,Qinhuangdao,Hebei 066004,P.R.China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100000,P.R.China;Qinhuangdao Haigang Hospital,Qinhuangdao,Hebei 066004,P.R.China)

机构地区：[1]燕山大学电气工程学院,河北秦皇岛066004 [2]北京中医药大学东直门医院,北京100000 [3]秦皇岛市海港医院,河北秦皇岛066004

出　　处：《生物医学工程学杂志》2020年第4期652-660,共9页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(61601106);河北省自然科学基金资助项目(F2016203443,H2018501067,F2019501101)。

摘　　要：特发性血小板减少性紫癜(ITP)是常见的血液性疾病,儿童发病率较高,但其诊断方法是排除性诊断,且现有检测技术多是有创的,可能会对患者造成二次伤害,增加临床风险。为弥补现有检测技术上的不足,本研究从红外热像的角度对儿童ITP的诊断做初步探索。本文试验共采集11个健康儿童和22个ITP儿童的正面红外热像,提取7个目标区域的花斑特征(PFD)、平均温度(Troi)特征与最高温度(MAX)特征,将加权后的PFD参数与临床诊断过程中常用的血小板计数做相关分析,并通过受试者工作特征曲线(ROC)计算加权后的PFD参数对儿童ITP的敏感性和特异性。最终研究结果显示,加权后的PFD参数在健康儿童和ITP儿童之间的差异有统计学意义,且与血小板计数呈负相关。在ROC曲线下,该参数的曲线下面积(AUC)高达92.1%。基于本文研究结果表明,通过红外热像能够清楚地表现出ITP儿童与健康儿童之间的差异,期望通过本文提出的方法可以无创地客观描述儿童ITP红外热像特征,为今后ITP的诊断提供新的思路。Idiopathic thrombocytopenic purpura(ITP)is a common bloody disease with a high incidence in children,but its diagnostic method is exclusive diagnosis,and the existing detection techniques are mostly invasive,which may cause secondary injury to patients and also may increase the risk of disease.In order to make up for the lack of the detection method,this study made a preliminary exploration on the diagnosis of children’s ITP from the perspective of infrared thermography.In this study,a total of 11 healthy children and 22 ITP children’s frontal infrared thermal images were collected,and the pattern characteristic(PFD),average temperature(Troi)and maximum temperature(MAX)characteristics of 7 target areas were extracted.The weighted PFD parameters were correlated with the platelet count commonly used in clinical diagnosis,and the sensitivity and specificity of the weighted PFD parameters for children’s ITP were calculated through the receiver operating characteristic curve(ROC).The final results showed that the difference of the weighted PFD parameters between healthy children and ITP children was statistically significant,and the parameters negatively correlated with platelet count.Under the ROC curve,the area under the curve(AUC)of this parameter is as high as 92.1%.Based on the research results of this paper,infrared thermography can clearly show the difference between ITP children and healthy children.It is hoped that the methods proposed in this paper can non-invasively and objectively describe the characteristics of ITP infrared thermal imaging of children,and provide a new ideas for ITP diagnosis.

关 键 词：红外热像 儿童特发性血小板减少性紫癜 血小板计数 评价方法 

分 类 号：R725.5[医药卫生—儿科]