18-氟脱氧葡萄糖正电子发射计算机断层显像/计算机断层扫描在炎症和感染性疾病中的应用  

The application of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography in inflammation and infectious disease

作　　者：姚玉唐(综述) 欧晓红(审校)[1] YAO Yutang;OU Xiaohong(Department of Nuclear Medicine,West China Hospital,Sichuan University,Chengdu 610041,P.R.China;PETCT center,Department of Nuclear Medicine,Sichuan Cancer Hospital&Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院核医学科,成都610041 [2]四川省肿瘤医院·研究所,四川省癌症防治中心,电子科技大学医学院核医学科PETCT中心,成都610041

出　　处：《生物医学工程学杂志》2020年第4期730-735,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(81271602)。

摘　　要：2-[18F]-氟-2-脱氧-D-葡萄糖(18F-FDG)-正电子发射计算机断层显像/计算机断层扫描(PET/CT)融合了正电子发射计算机断层显像(PET)和计算机断层扫描(CT)成像技术,可评估不同状况下机体的糖代谢变化。目前该影像技术除了应用于肿瘤之外,也可在炎症和感染性疾病的诊疗中发挥重要作用。18F-FDG PET/CT能在形态学变化之前识别感染症状的来源、显示炎性病变累及范围、指导组织活检部位以及评估治疗反应。本文就18F-FDG PET/CT在炎性病变,如不明原因发热(FUO)、结节病、血管炎、骨髓炎、关节假体或植入物相关并发症、人类免疫缺陷病毒相关感染、炎性肠病以及其他炎性病变诊治中的应用进展进行综述,以期能为临床医师选择PET/CT帮助诊治炎性疾病提供参考。2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography(18F-FDG PET/CT)combining positron emission tomography with computed tomography is used to evaluate the body’s glucose metabolic changes under different conditions.In addition to its established role in oncological imaging,18F-FDG PET/CT has clinical utility in suspected inflammation and infection.The technique can identify the source of infection in a timely fashion ahead of morphological changes,map the extent and severity of inflammation,guide the site for tissue biopsy and assess therapy response.This article reviewed the use of 18F-FDG PET/CT in infection and inflammation,such as fever of unknown origin,sarcoidosis,vessel vasculitis,osteomyelitis,joint prosthesis or implant-related complications,human immunodeficiency virus-related infections,and other indications,such as inflammatory bowel disease,so as to provide reference for clinicians to select 18F-FDG PET/CT to help them in the diagnosis and treatment of inflammatory diseases.

关 键 词：2-[18F]-氟-2-脱氧-D-葡萄糖 正电子发射计算机断层显像/计算机断层扫描 炎症 感染 

分 类 号：R73[医药卫生—肿瘤]